Chapter 7 MCQs

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. Which one of the following would NOT be regarded as a key factor in the design of a drug synthesis?

Availability of starting materials correct incorrect

Reaction yield at each stage correct incorrect

Compatibility with large-scale manufacturing correct incorrect

Use of stereospecific reactions correct incorrect

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. Which of the following would NOT be used as a carbocation synthon?

Grignard reagent correct incorrect

Amide correct incorrect

Alcohol correct incorrect

Alkyl halide correct incorrect

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. Which of the following is NOT a protecting group?

Benzyl ether correct incorrect

Trityl ether correct incorrect

Peroxide correct incorrect

Trifluoroacetate correct incorrect

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. Which of the following drugs does NOT exhibit differences in type of biological activity between isomers?

Propranolol correct incorrect

Promethazine correct incorrect

Diazepam correct incorrect

Ketamine correct incorrect

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. Which of the following would NOT be used to achieve a stereospecific reaction?

Use of enzyme catalysts correct incorrect

Use of chiral auxiliaries correct incorrect

Use of a resolving agent correct incorrect

Use of chiral starting materials correct incorrect

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. Which of the following would be produced by genetic engineering?

Morphine correct incorrect

Insulin correct incorrect

Ranitidine correct incorrect

Salbutamol correct incorrect

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. Retrosynthetic analysis is used in designing a drug synthesis because

it can easily identify cheap starting materials. correct incorrect

it can identify commercially available starting materials. correct incorrect

it involves breaking the desired product into smaller structures. correct incorrect

it involves theoretically disconnecting the desired structure into synthons. correct incorrect

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. Which of the following statements about convergent synthesis is FALSE?

The overall yield of the final product is likely to be lower than that of a linear synthesis. correct incorrect

The overall yield of the final product is likely to be higher than that of a linear synthesis. correct incorrect

The more convergent pathways that are used, the higher the overall yield of the final product will be. correct incorrect

Convergent synthesis is more useful if a multi-step synthesis is required. correct incorrect

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. Which of the following statements about diversity-oriented synthesis is FALSE?

It can provide a wide range of structural analogues. correct incorrect

It involves modification of functional groups. correct incorrect

It involves the introduction of new substituents. correct incorrect

It involves significant changes to the overall synthetic process. correct incorrect

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. For which of the following reasons is semi-synthesis of natural products NOT utilised?

The natural products are often present in small quantities. correct incorrect

It is often an attempt to improve on the therapeutic activity of the natural product. correct incorrect

It is an attempt to control the chirality of the natural product. correct incorrect

It is often an attempt to reduce the toxicity of the natural product. correct incorrect