Chapter 6 MCQs

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. Paclitaxel, the potent anti-cancer drug, was isolated from which natural source?

The Pacific yew tree correct incorrect

The Pacific ocean correct incorrect

A fungus correct incorrect

A bacterium correct incorrect

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. Which of the following drugs was inspired by nature?

Morphine correct incorrect

Salbutamol correct incorrect

Citalopram correct incorrect

Erythromycin correct incorrect

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. What is a semi-synthetic drug?

A drug isolated from nature and used without any further modification correct incorrect

A drug synthesised entirely from scratch in a laboratory correct incorrect

The structure of a drug halfway through its synthesis correct incorrect

A drug that has been part-made by nature and part-made in the laboratory correct incorrect

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. What is 'simplification' when referred to in drug development terms?

The process by which a drug candidate is synthesised as simply as possible correct incorrect

The process of adding more chiral centres to a molecule to make it bind more easily to its biological target correct incorrect

The process of removing unimportant functionalities from a lead compound in the hope of maintaining activity but making the resulting compound cheaper and easier to synthesise correct incorrect

The process of shortening the drug development process from the discovery phase to the clinical trial phase correct incorrect

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. Why may omeprazole be considered a 'me-too' drug?

Because it is comparable in dosage, dosage form and clinical usage to an existing drug correct incorrect

Because it is manufactured by the same company as an already existing drug in an attempt to prolong the patent life correct incorrect

Because its structure is identical to an already known drug correct incorrect

Because it is a drug that works by the same mechanism as an already known drug correct incorrect

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. Which of the following drugs was NOT discovered as a result of serendipity?

Sildenafil correct incorrect

Iproniazid correct incorrect

Diamorphine correct incorrect

Propranolol correct incorrect

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. Which area of the world has poorly developed documentation relating to the use of naturally occurring medicines?

China correct incorrect

Sub-Saharan Africa correct incorrect

India correct incorrect

Middle East correct incorrect

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. Which of the following is NOT a reason for the failure to develop useful drugs from the endogenous opiates?

They have a very short duration of action. correct incorrect

They induce tolerance. correct incorrect

They induce dependence. correct incorrect

They are difficult to synthesise. correct incorrect

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. Why was the toxicity of thalidomide not discovered prior to marketing?

Its solubility was not tested. correct incorrect

Initial in vivo testing was carried out only in mice. correct incorrect

It was tested as the racemate. correct incorrect

There was no requirement for toxicity testing at the time. correct incorrect

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. To date, which natural source has been the least successful in terms of yielding clinically active drugs?

Marine sources correct incorrect

Plant sources correct incorrect

Microorganisms correct incorrect

Venoms and toxins correct incorrect