Chapter 3 MCQs

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. Which statement about enzymes is true?

Enzymes enable a greater quantity of product to form. correct incorrect

Enzymes alter the rate of reaction. correct incorrect

Enzymes increase the activation energy required for a reaction to take place. correct incorrect

Enzymes alter the position of a reaction equilibrium. correct incorrect

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. Which of the following drugs is NOT an irreversible enzyme inhibitor?

Atorvastatin correct incorrect

Aspirin correct incorrect

Tranylcypromine correct incorrect

Penicillin correct incorrect

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. Which of the following biochemical processes exploit selective toxicity between the target bacterial organism and the human host?

Glycolysis correct incorrect

TCA cycle correct incorrect

Biosynthesis of folate correct incorrect

Biosynthesis of peptidoglycans correct incorrect

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. Antibiotic resistance CANNOT arise by which ONE of the following means?

Production of β-lactamases correct incorrect

Transfer of genetic material to plasmids correct incorrect

Covalent binding to enzymes correct incorrect

Bacterial mutation correct incorrect

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. Which of the following enzymes is inhibited by trimethoprim?

Dihydropteroate synthase correct incorrect

Acetylcholinesterase correct incorrect

Cyclooxygenase correct incorrect

Dihydrofolate reductase correct incorrect

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. Which ONE of the following is NOT a challenge to the use of enzymes as a drug target?

Selectivity correct incorrect

Metabolic inactivation correct incorrect

Lack of oral activity correct incorrect

Cell permeability correct incorrect

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. Which of the following statements best describes the role of enzymes as therapeutic targets?

Very few drugs exert their effects by interacting with enzymes. correct incorrect

Drugs targeting enzymes usually activate their target enzyme. correct incorrect

Drugs often work by enhancing the binding of an enzyme's normal substrate. correct incorrect

Drugs targeting enzymes are often very specific and can be less likely to produce side effects. correct incorrect

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. Which ONE of the following biochemical processes is a class II biochemical reaction?

Biosynthesis of folate correct incorrect

Glycolysis correct incorrect

Transpeptidation correct incorrect

Citric acid cycle correct incorrect

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. Which ONE of the following is a prodrug?

Low-dose aspirin correct incorrect

Trimethoprim correct incorrect

Vancomycin correct incorrect

Azathioprine correct incorrect

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. Which type of enzyme inhibitor could be used to map an enzyme active site?

Reversible inhibitor correct incorrect

Non-competitive inhibitor correct incorrect

Irreversible inhibitor correct incorrect

Allosteric inhibitor correct incorrect