Chapter 16 MCQs

* not completed

. Which of the following is NOT a crystal unit cell?

Cubic correct incorrect

Diclinic correct incorrect

Orthorhombic correct incorrect

Hexagonal correct incorrect

* not completed

. Which of the following is NOT a crystal habit?

Planar correct incorrect

Columnar correct incorrect

Plate correct incorrect

Acicular correct incorrect

* not completed

. Which of the following properties does NOT vary between polymorphic forms?

Melting temperature correct incorrect

Solubility correct incorrect

Hydrophobicity correct incorrect

Dissolution rate correct incorrect

* not completed

. Which of the following is a disadvantage of DSC as a method of characterising polymorphs?

Provides thermodynamic information correct incorrect

Allows identification of stable and unstable polymorphs correct incorrect

Allows identification of polymorphs as monotropic or enantiotropic correct incorrect

Is potentially a destructive method of analysis correct incorrect

* not completed

. A metastable polymorph of chloramphenicol palmitate is used clinically because

it is the most stable polymorph. correct incorrect

it is the most unstable polymorph. correct incorrect

it is poorly soluble. correct incorrect

it has a rapid dissolution rate. correct incorrect

* not completed

. Which of the following is NOT a reason to avoid clinical usage of a hydrate?

Presence of water can lead to dehydration/rehydration during storage. correct incorrect

Presence of water can lead to formation of hydrogen bonds with other compounds in the formulation. correct incorrect

Possible toxicity problems. correct incorrect

Presence of water can lead to reduced solubility. correct incorrect

* not completed

. Which of the following processing methods is less likely to produce amorphous material?

Quench-cooling correct incorrect

Freeze-drying correct incorrect

Spray-drying correct incorrect

Milling correct incorrect

* not completed

. Which of the following is NOT a common powder particle shape?

Triclinic correct incorrect

Spherical correct incorrect

Angular correct incorrect

Cylindrical correct incorrect

* not completed

. Particle size is an important factor in pharmaceutical manufacturing. Which of the following manufacturing properties would NOT be affected by particle size?

Flowability correct incorrect

Bioavailability correct incorrect

Compactability correct incorrect

Uniformity of content correct incorrect

* not completed

. Which of the following combinations of compressibility index (%) and angle of repose (θ) would be unacceptable as powder flow properties?

Compressibility index < 10%, angle of repose < 30° correct incorrect

Compressibility index 15%, angle of repose 32° correct incorrect

Compressibility index 20%, angle of repose 35° correct incorrect

Compressibility index 35 %, angle of repose >56° correct incorrect