Chapter 15 MCQs

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. Which of the following is the correct defined pharmacopoeial solubility range for 'sparingly soluble'?

< 0.1 mg ml^-1 correct incorrect

1-10 mg ml^-1 correct incorrect

10-33 mg ml^-1 correct incorrect

10-1000mg ml^-1 correct incorrect

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. Which one of the following biopharmaceutical classification classes represents low solubility and high intestinal permeability?

1 correct incorrect

2 correct incorrect

3 correct incorrect

4 correct incorrect

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. Which of the following conditions is NOT usually used in the determination of the equilibrium solubility of a potential drug substance?

Preparation of a saturated solution of the substance. correct incorrect

Establishment of an equilibrium between dissolved and undissolved solute. correct incorrect

The equilibrium is established over a period of 24 hours. correct incorrect

An appropriate analytical method is used for the substance in solution. correct incorrect

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. Which of the following temperatures is NOT usually employed in solubility studies?

4°C correct incorrect

25°C correct incorrect

37°C correct incorrect

50°C correct incorrect

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. Which of the following is NOT regarded as a potential positive of salt formation of a drug?

Increased solubility correct incorrect

Increased number of polymorphs correct incorrect

Higher bioavailability correct incorrect

Increased dissolution rate correct incorrect

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. Which of the following reasons may be why formation of a hydrochloride salt of a drug may NOT be utilised?

Hydrochloride ions are physiologically present. correct incorrect

Hydrochloride ions occur as physiological metabolites. correct incorrect

Hydrochloride salts generally have increased solubility. correct incorrect

Hydrochloride salts may have reduced in vivo solubility because of the common ion effect. correct incorrect

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. Which of the following drugs would you expect to have a negative log P value?

Benzocaine correct incorrect

Methadone correct incorrect

Levodopa correct incorrect

Hydrocortisone correct incorrect

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. According to the Noyes-Whitney equation, which of the following is NOT involved in the dissolution rate of a solid dosage form?

Solid/liquid interface area correct incorrect

The volume of the bulk solvent correct incorrect

The thickness of the diffusion layer correct incorrect

The concentration of the solid in the diffusion layer correct incorrect

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. The standard pharmacopoeial dissolution test uses 900-1000ml of 0.1 M HCl/phosphate buffer. Which of the following changes would NOT give a more realistic measure of in vivo dissolution rate?

Reduction in volume of dissolution fluid correct incorrect

Use of simulated gastrointestinal fluids correct incorrect

Inclusion of chloride ions correct incorrect

Use of different temperatures correct incorrect

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. Which of the following is NOT a technique for improving the formulation of a poorly soluble drug?

Drug precipitation correct incorrect

Particle engineering correct incorrect

Solid dispersion correct incorrect

Complex formation correct incorrect