Chapter 14 MCQs

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. Which of the following reasons for carrying out non-clinical toxicity testing is NOT a requirement?

It is a regulatory requirement. correct incorrect

It supports clinical trials. correct incorrect

It informs drug development. correct incorrect

It is responsible for the termination of about 30% of new drug developments. correct incorrect

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. Which of the following is NOT involved in non-clinical toxicity testing?

Specific organ toxicity correct incorrect

Genetic material toxicity correct incorrect

Reproductive toxicity correct incorrect

Species-specific toxicity correct incorrect

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. Which of the following is NOT usually involved in carcinogenicity testing?

Cellular testing correct incorrect

Structural comparison with known carcinogens correct incorrect

One long-term in vivo study in rodents correct incorrect

One short-term study in rodents correct incorrect

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. Which of the following is NOT involved in mutagenicity testing?

A computer-based study correct incorrect

An in vitro bacterial test for gene mutation correct incorrect

A mammalian cell mutation assay correct incorrect

A micromass test correct incorrect

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. Which of the following is NOT a mutagenicity toxicity test?

Ames test correct incorrect

Assessment of development toxicology correct incorrect

Comet assay correct incorrect

Clastogenicity test correct incorrect

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. Which of the following drugs is NOT a potential teratogen?

Lisinopril correct incorrect

Doxycycline correct incorrect

Codeine correct incorrect

Thalidomide correct incorrect

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. Which of the following is NOT involved in immunotoxicity testing?

Immunosuppression correct incorrect

Bone marrow micromass test correct incorrect

Enhanced immune activation correct incorrect

Autoimmunity correct incorrect

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. Which of the following is NOT a core study involved in safety pharmacology testing?

Route of metabolism correct incorrect

Central nervous system correct incorrect

Cardiovascular system correct incorrect

Respiratory system correct incorrect

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. Which of the following is NOT an in vitro cell viability test?

Alamar Blue assay correct incorrect

ELISA assay correct incorrect

MTT assay correct incorrect

NRU assay correct incorrect

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. Which of the following statements is INCORRECT?

Acute toxicity testing is usually of 24-hour duration. correct incorrect

Acute toxicity testing involves two mammalian species. correct incorrect

Acute toxicity testing involves one route of administration. correct incorrect

Acute toxicity testing requires the use of two animal species: one rodent and one non-rodent. correct incorrect