Chapter 12 MCQs

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. Which of the following is the principal site of metabolism in the body?

Blood correct incorrect

Brain correct incorrect

Kidney correct incorrect

Liver correct incorrect

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. In which of the following sites does oxidative metabolism NOT take place?

Liver correct incorrect

Gastrointestinal tract correct incorrect

Lungs correct incorrect

Skin correct incorrect

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. Which of the following does NOT occur in Phase I metabolism?

Conjugation correct incorrect

Hydrolysis correct incorrect

Oxidation correct incorrect

Reduction correct incorrect

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. Which of the following drugs is NOT involved in oxidative metabolism?

Warfarin correct incorrect

Chlorpromazine correct incorrect

Procaine correct incorrect

Cimetidine correct incorrect

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. Which of these functional groups is unlikely to be involved in reductive metabolism?

Nitro group correct incorrect

Aldehyde group correct incorrect

Ketone group correct incorrect

Ester group correct incorrect

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. Which of the following enzymes is NOT involved in hydrolytic metabolism?

Monoamine oxidase correct incorrect

Pseudocholinesterase correct incorrect

Carboxypeptidase correct incorrect

Aminopeptidase correct incorrect

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. Which of the following endogenous substances is NOT involved in Phase II metabolism?

Glucuronic acid correct incorrect

Formate correct incorrect

Glutathione correct incorrect

Acetate correct incorrect

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. Which of the following factors that can affect drug metabolism is the least significant?

Age correct incorrect

Disease correct incorrect

Gender correct incorrect

Diet correct incorrect

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. Which of the following is NOT a prodrug?

Methylprednisolone sodium succinate correct incorrect

Enalapril correct incorrect

Levodopa correct incorrect

Naloxone correct incorrect

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. The toxicity of benzo-[a]-pyrene is due to

its polyaromaticity. correct incorrect

its conversion to a toxic metabolite. correct incorrect

its lipophilicity. correct incorrect

its rapid absorption. correct incorrect