Chapter 11 MCQs

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. Which of the following is NOT classified as a biopharmaceutical product?

Insulin correct incorrect

Tamoxifen correct incorrect

Interleukin 1 correct incorrect

Tumour necrosis factor correct incorrect

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. Which of the following is NOT produced by biotechnology methods?

β-Lactams correct incorrect

Tetracyclines correct incorrect

Macrolides correct incorrect

Sulfonamides correct incorrect

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. Which of the following processes is NOT involved in recombinant DNA technology?

Isolating a gene of interest correct incorrect

Producing a vector correct incorrect

Selecting a transgenic host correct incorrect

Propagating the host correct incorrect

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. Which of the following is NOT a requirement for a successful recombinant DNA technique?

There must be an efficient method for cleaving and re-joining genes. correct incorrect

There must be suitable vectors capable of replicating foreign DNA. correct incorrect

There must be a means of introducing the recombinant DNA into a host organism. correct incorrect

There must be a method of retrieving the recombinant DNA from the host organism. correct incorrect

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. Which of the following is NOT a source used for the production of recombinant DNA?

Genomic DNA correct incorrect

DNA libraries correct incorrect

Damaged DNA correct incorrect

Synthesized DNA correct incorrect

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. Which of the following statements about bacteriophages is FALSE?

They are smaller than plasmids. correct incorrect

They are bacterial viruses. correct incorrect

They contain up to 500,000 base pairs. correct incorrect

They can accommodate large amounts of passenger DNA. correct incorrect

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. Which of the following is NOT used as host cells in recombinant DNA technology?

Viruses correct incorrect

Bacterial cells correct incorrect

Yeast cells correct incorrect

Mammalian cells correct incorrect

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. Which of the following techniques is NOT used in the purification of recombinant protein?

Differential centrifugation correct incorrect

Gas-liquid chromatography correct incorrect

Gel filtration correct incorrect

Ion-exchange chromatography correct incorrect

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. Which of the following is NOT a challenge to the use of recombinant proteins as drugs?

They are poorly absorbed. correct incorrect

They are susceptible to degradation by proteolytic enzymes. correct incorrect

They do not bind to endogenous proteins. correct incorrect

They may trigger an immune response. correct incorrect

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. Which of the following is classified as monoclonal antibody therapy?

Treatment of Crohn's disease with Infliximab correct incorrect

Treatment of non-Hodgkin's lymphoma with Rituximab correct incorrect

Treatment of lymphocytic leukaemia with Alemtuzumab correct incorrect

Treatment of cytomegalovirus retinitis with Fomivirsen correct incorrect