Chapter 10 MCQs

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. Which of the following processes is NOT involved in solid-phase synthesis of peptides?

Coupling correct incorrect

Deprotection correct incorrect

Cyclization correct incorrect

Cleavage correct incorrect

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. Which of the following is NOT a requirement of a combinatorial chemistry reaction?

Formation of a covalent bond between building blocks correct incorrect

Suitability for large-scale reaction correct incorrect

High yield correct incorrect

Readily available building blocks correct incorrect

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. Which of the solid-phase synthetic support methods can be adapted to produce multi-mg quantities of product?

Bead support correct incorrect

Chip support correct incorrect

Pin support correct incorrect

Tea-bag support correct incorrect

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. Which of the following processes is NOT involved in the 'pool and split' approach to solid-phase support synthesis?

Each solid support material (e.g. bead) has a different structure attached. correct incorrect

Different beads are mixed and undergo the same reaction. correct incorrect

The resulting beads are separated. correct incorrect

The beads are tested for biological activity as a mixture. correct incorrect

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. Which of the following methods of tagging is NOT used in 'pool and split' synthetic methods?

Radioactive labelling correct incorrect

Chemical tagging correct incorrect

Radiofrequency chip tagging correct incorrect

Barcoding correct incorrect

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. Deconvolution is an important process in combinatorial synthesis. Which of the following statements about deconvolution is TRUE?

Deconvolution is the process by which the number of screening tests required to identify the most active member of a combinatorial library is increased. correct incorrect

In iterative deconvolution, the size of the combinatorial library is gradually reduced. correct incorrect

In subtraction deconvolution, building blocks are added to a combinatorial library in order to identify the most active compound. correct incorrect

Iterative deconvolution is more effective if there is more than one active compound in the initial combinatorial library. correct incorrect

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. Which of the following analytical techniques is NOT useful in combinatorial synthesis?

HPLC-MS correct incorrect

LC-MS correct incorrect

IR-MS correct incorrect

GC-MS correct incorrect

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. Which of the following statements about the format of combinatorial libraries is FALSE?

An unbiased library is typically based on a common chemical scaffold. correct incorrect

A directed library is based on a common chemical scaffold. correct incorrect

Tagged libraries are used to produce compounds in mg quantities. correct incorrect

Spatially addressed libraries tend to utilise fully automated workstations. correct incorrect

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. Which of the following statements about high throughput screening is FALSE?

It is designed to screen large numbers of compounds. correct incorrect

It screens compounds in a number of biological assays simultaneously. correct incorrect

It requires significant quantities of each compound tested. correct incorrect

It is usually a highly automated process. correct incorrect

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. Which of the following statements about the biological assays in high throughput screening is FALSE?

They must be accurate. correct incorrect

They must be reproducible. correct incorrect

They must have a high signal-to-noise ratio. correct incorrect

They must produce a precise numerical value. correct incorrect