Chapter 7 Multiple Choice Questions

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. With respect to the electrophilic aromatic substitution of benzene which of the following is not true

A non-aromatic intermediate is formed correct incorrect

Benzene acts as an electrophile correct incorrect

A proton is lost in the final step correct incorrect

Resonance forms are important correct incorrect

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. In the body many mono-substituted aromatic compounds are metabolised…

To the para-fluoro compound which may be prevented by the addition of a para-hydroxy group correct incorrect

By G-protein coupled receptors correct incorrect

To less polar compounds correct incorrect

To the para-hydroxy compound which may be prevented by the addition of a para-fluoride correct incorrect

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. Which of the following statements is incorrect: aromatic compounds…

Are planar correct incorrect

Have 4n π-electrons correct incorrect

Are cyclic correct incorrect

Are generally less reactive than similarly substituted alkenes correct incorrect

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. When considering electrophilic aromatic substitution reactions electron withdrawing substituents (e.g. nitro) are described as…

Ortho/para directing and activating correct incorrect

Ortho/para directing and deactivating correct incorrect

Meta directing and activating correct incorrect

Meta directing and deactivating correct incorrect

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. The Friedel-Crafts alkylation…

Works very well for primary chlorides correct incorrect

Works very well for tertiary chlorides correct incorrect

Works very well for acyl chlorides correct incorrect

Works very well without a catalyst correct incorrect

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. Paracetamol is an effective analgesic: which of the following statements is NOT true?

It can be synthesised from phenol. correct incorrect

The first step in the synthesis is nitration of phenol to produce the ortho and para isomers of nitrophenol. correct incorrect

The 4-nitrophenol has a lower boiling point than 2-nitrophenol and can be readily removed by distillation. correct incorrect

The 4-nitrophenol is reduced and then acetylated to produce paracetamol. correct incorrect

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. When considering electrophilic aromatic substitution reactions the halides are described as:

Ortho/para directing and activating correct incorrect

Ortho/para directing and deactivating correct incorrect

Meta directing and activating correct incorrect

Meta directing and deactivating correct incorrect

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. When considering electrophilic aromatic substitution reactions electron donating subsituents (e.g. methoxy) are described as:

Ortho/para directing and activating correct incorrect

Ortho/para directing and deactivating correct incorrect

Meta directing and activating correct incorrect

Meta directing and deactivating correct incorrect

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. With respect to the electrophilic aromatic substitution of benzene which of the following is not true:

A non-aromatic intermediate is formed correct incorrect

Benzene acts as an electrophile correct incorrect

A proton is lost in the final step correct incorrect

Resonance forms are important correct incorrect

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. Which of the following drugs does not contain an aromatic species? You should use this opportunity to get some background on the well known drugs listed.

Salbutamol correct incorrect

Imatinib correct incorrect

Valsartan correct incorrect

Pregabalin correct incorrect

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. Which of the following is not associated with electrophilic aromatic substitution?

The formation of nitrobenzene correct incorrect

The formation of benzyne correct incorrect

The formation of bromobenzene correct incorrect

The formation of benzene sulfonic acid correct incorrect