Chapter 14 Multiple Choice Questions

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. Which of the following drugs has the largest apparent volume of distribution?

Ibuprofen correct incorrect

Ampicillin correct incorrect

Morphine correct incorrect

Aspirin correct incorrect

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. Which of the following is the principal site of metabolism in the body?

Blood correct incorrect

Brain correct incorrect

Kidney correct incorrect

Liver correct incorrect

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. Which of the following does NOT occur in Phase I metabolism?

Conjugation correct incorrect

Hydrolysis correct incorrect

Oxidation correct incorrect

Reduction correct incorrect

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. Which of the following drugs is NOT involved in oxidative metabolism?

Warfarin correct incorrect

Chlorpromazine correct incorrect

Procaine correct incorrect

Cimetidine correct incorrect

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. Which of these functional groups is unlikely to be involved in reductive metabolism?

Nitro group correct incorrect

Aldehyde group correct incorrect

Ketone group correct incorrect

Ester group correct incorrect

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. Which of the following enzymes is NOT involved in hydrolytic metabolism?

Monoamine oxidase correct incorrect

Pseudocholinesterase correct incorrect

Carboxypeptidase correct incorrect

Aminopeptidase correct incorrect

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. Which of the following endogenous substances is NOT involved in Phase II metabolism?

Glucuronic acid correct incorrect

Formate correct incorrect

Glutathione correct incorrect

Acetate correct incorrect

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. Which of the following statements about cytochrome P450 enzymes is NOT true?

Cytochrome P450 enzymes are always involved in oxidative metabolism. correct incorrect

Cytochrome P450 enzymes form complexes with carbon dioxide which absorb light of about 450nm. correct incorrect

Cytochrome P450 enzymes all contain a Fe²⁺ atom. correct incorrect

Cytochrome P450 enzymes are coordinated with a molecule of water which can be replaced by oxygen. correct incorrect

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. Which of the following statements about renal excretion of drugs is NOT true?

Drugs are excreted by the kidney by glomerular filtration and tubular secretion. correct incorrect

Glomerular filtration is a passive diffusion process. correct incorrect

Tubular secretion is an active transport process. correct incorrect

Both acidic and basic drugs are secreted into the renal tubules by the same active transport system. correct incorrect

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. Which of the following drugs has the longest half-life (t_1/2)?

Warfarin correct incorrect

Chlorpromazine correct incorrect

Ranitidine correct incorrect

Heparin correct incorrect