Chapter 13 Multiple Choice Questions

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. Who makes the active components of medicines?

Pharmacists correct incorrect

Chemists correct incorrect

Doctors correct incorrect

Pharmacologists correct incorrect

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. Aspirin is converted into salicylic acid in your body by which of the following reactions?

Hydrolysis correct incorrect

Oxidation correct incorrect

Reduction correct incorrect

Substitution correct incorrect

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. The structure of diamorphine differs from that of morphine by the addition of which functional group or groups?

One acetyl group correct incorrect

One methyl group correct incorrect

Two acetyl groups correct incorrect

Two methyl groups correct incorrect

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. What kind of antibacterial agent is erythromycin?

A macrolide correct incorrect

A penicillin correct incorrect

A cephalosporin correct incorrect

A tetracycline correct incorrect

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. You can usually tell if a drug is a natural product because:

its structure is very simple correct incorrect

its structure contains lots of chiral centres and is very complex correct incorrect

you can't tell just by looking at its structure correct incorrect

None of the above correct incorrect

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. What is a semi-synthetic drug?

A drug isolated from nature and used without any further modification correct incorrect

A drug made entirely in a lab from scratch correct incorrect

The structure of a drug half-way through its preparation correct incorrect

A drug which has been part-made by nature and part-made in a lab correct incorrect

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. Paclitaxel, the potent anticancer drug, was isolated from which natural source?

The Pacific Yew tree correct incorrect

The Pacific Ocean correct incorrect

A fungus correct incorrect

A bacteria correct incorrect

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. What is 'simplification' when referred to in drug development terms?

The process by which a drug candidate is synthesised as simply as possible correct incorrect

The process of adding more chiral centres to a compound to make it bind more easily to its biological target correct incorrect

The process of removing unimportant groups from a lead compound in the hope of maintaining activity but rendering the resulting compounds cheaper and easier to make correct incorrect

The process of shortening the drug development process from the discovery stage to its clinical trials stage correct incorrect

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. Why may esomeprazole be considered a 'me-too' drug?

Because it is comparable in dose, dosage form, and intended use to an already known drug correct incorrect

Because it is manufactured by the same company as that of an already known drug correct incorrect

Because its structure is identical to an already known drug correct incorrect

Because it is a drug which works through the same mechanism as an already known drug correct incorrect

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. Which of the following drugs was inspired by nature?

Morphine correct incorrect

Salbutamol correct incorrect

Citalopram correct incorrect

Erythromycin correct incorrect