Serotonin

Serotonin Synthesis, Release, and Inactivation

Serotonin synthesis is regulated by enzymatic activity and precursor availability

Similar processes regulate storage, release, and inactivation of serotonin and the catecholamines

Box 6.1 History of Psychopharmacology  “Ecstasy”—Harmless Feel-Good Drug, Dangerous Neurotoxin, or Miracle Medication?

Organization and Function of the Serotonergic System

The serotonergic system originates in the brainstem and projects to all forebrain areas

The firing of dorsal raphe serotonergic neurons varies with behavioral state and in response to rewards and punishments

There is a large family of serotonin receptors, most of which are metabotropic

Multiple approaches have identified several behavioral and physiological functions of serotonin

Box 6.2 The Cutting Edge Serotonin and Aggression