Psychopharmacology 3e Chapter 19 Outline

Schizophrenia: Antipsychotic Drugs


Characteristics of Schizophrenia

There is no defining cluster of schizophrenic symptoms

Etiology of Schizophrenia

Abnormalities of brain structure and function occur in individuals with schizophrenia
Genetic, environmental, and developmental factors interact
Box 19.1 The Cutting Edge Epigenetic Modifications and Risk for Schizophrenia

Preclinical Models of Schizophrenia

Box 19.2 Pharmacology In Action The Prenatal Inflammation Model of Schizophrenia

Neurochemical Models of Schizophrenia

Abnormal dopamine function contributes to schizophrenic symptoms
The neurodevelopmental model integrates anatomical and neurochemical evidence
Glutamate and other neurotransmitters contribute to symptoms

Classic Neuroleptics and Atypical Antipsychotics

Phenothiazines and butyrophenones are classic neuroleptics
Dopamine receptor antagonism is responsible for antipsychotic action
Side effects are directly related to neurochemical action
Atypical antipsychotics are distinctive in several ways
Practical clinical trials help clinicians make decisions about drugs
There are renewed efforts to treat the cognitive symptoms