Psychopharmacology 3e Chapter 18 Outline

Affective Disorders: Antidepressants and Mood Stabilizers


Characteristics of Affective Disorders

Major depression damages the quality of life
In bipolar disorder moods alternate from mania to depression
Risk factors for mood disorders are biological and environmental

Animal Models of Affective Disorders

Models of bipolar disorder

Neurochemical Basis of Mood Disorders

Serotonin dysfunction contributes to mood disorders
Norepinephrine activity is altered by antidepressants
Norepinephrine and serotonin modulate one another

Neurobiological Models of Depression

Box 18.1 The Cutting Edge Epigenetic Modifications in Psychopathology and Treatment

Therapies for Affective Disorders

Monoamine oxidase inhibitors are the oldest antidepressant drugs
Tricyclic antidepressants block the reuptake of norepinephrine and serotonin
Second-generation antidepressants have different side effects
Third-generation antidepressants have distinctive mechanisms of action
Drugs for treating bipolar disorder stabilize the highs and the lows