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Return to Psychopharmacology 3e Student Resources
Psychopharmacology 3e Chapter 15 Outline
Hallucinogens, PCP, and Ketamine
Hallucinogenic Drugs
Mescaline
Psilocybin
Dimethyltryptamine and Related Tryptamines
LSD
Box 15.1 History of Pharmacology
The Discovery of LSD
NBOMes
Salvinorin A
Pharmacology of Hallucinogenic Drugs
Different hallucinogenic drugs vary in potency and in their time course of action
Hallucinogens produce a complex set of psychological and physiological responses
Most hallucinogenic drugs share a common indoleamine or phenethylamine structure
Indoleamine and phenethylamine hallucinogens are 5-HT
2A
receptor agonists
Salvinorin A is a κ-opioid receptor agonist
The neural mechanisms underlying hallucinogenesis are not yet fully understood
Hallucinogenic drug use leads to adverse effects in some users
Can hallucinogenic drugs be used therapeutically?
PCP and Ketamine
Background and History
Pharmacology of PCP and Ketamine
PCP and ketamine produce a state of dissociation
PCP and ketamine are noncompetitive antagonists of NMDA receptors
PCP and ketamine have significant abuse potential
Use of PCP, ketamine, or related drugs can cause a variety of adverse consequences
Box 15.2 Pharmacology In Action
Getting High on Cough Syrup
Novel therapeutic applications have been proposed for ketamine
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