Psychopharmacology 3e Chapter 15 Outline

Hallucinogens, PCP, and Ketamine


Hallucinogenic Drugs



Dimethyltryptamine and Related Tryptamines


Box 15.1 History of Pharmacology The Discovery of LSD


Salvinorin A

Pharmacology of Hallucinogenic Drugs

Different hallucinogenic drugs vary in potency and in their time course of action
Hallucinogens produce a complex set of psychological and physiological responses
Most hallucinogenic drugs share a common indoleamine or phenethylamine structure
Indoleamine and phenethylamine hallucinogens are 5-HT2A receptor agonists
Salvinorin A is a κ-opioid receptor agonist
The neural mechanisms underlying hallucinogenesis are not yet fully understood
Hallucinogenic drug use leads to adverse effects in some users
Can hallucinogenic drugs be used therapeutically?

PCP and Ketamine

Background and History

Pharmacology of PCP and Ketamine

PCP and ketamine produce a state of dissociation
PCP and ketamine are noncompetitive antagonists of NMDA receptors
PCP and ketamine have significant abuse potential
Use of PCP, ketamine, or related drugs can cause a variety of adverse consequences
Box 15.2 Pharmacology In Action Getting High on Cough Syrup
Novel therapeutic applications have been proposed for ketamine