Chapter 9 Multiple Choice Questions

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. The synthesis of complex natural products can prove challenging. Which of the following factors is not a contributing factor to this?

The number and variety of functional groups present correct incorrect

The presence of multicyclic or unusual ring systems correct incorrect

The lack of asymmetric centres correct incorrect

The number and variety of substituents correct incorrect

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. What is meant by a semi-synthetic approach in drug synthesis?

The synthesis of a drug from a natural product correct incorrect

The synthesis of a drug where part of the synthetic route involves the use of enzymes correct incorrect

The use of genetically modified microorganisms to produce a drug or its analogues correct incorrect

The synthesis of a structure, which is then fed to a micro-organism and converted to the drug by a biosynthetic pathway correct incorrect

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. What is meant by synthetic biology?

The synthesis of naturally occurring compounds. correct incorrect

The genetic modification of microbial cells such that they produce produce compounds that they would not normally produce. correct incorrect

The study of how naturally occurring compounds are biosynthesised in cells correct incorrect

The design and synthesis of enzymes capable of carrying out a specific reaction in organic synthesis correct incorrect

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. Which of the following penicillins cannot be produced by fermentation?

Structure A. correct incorrect

Structure B. correct incorrect

Structure C. correct incorrect

Structure D. correct incorrect

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. Many natural products contain a tertiary amine with a methyl substituent. What reagent is used to remove the methyl substituent in the following reaction sequence?

Lithium aluminium hydride correct incorrect

Sodium hydroxide. correct incorrect

Hydrogen chloride correct incorrect

Vinyloxycarbonyl chloride correct incorrect

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. Which of the following statements best describes combinatorial biosynthesis?

The creation of a chemical library where the reactions involved are enzyme-catalysed correct incorrect

The genetic modification of catalytic sites within a super-enzyme in order to generate a library of different superenzymes, which will in turn produce analogues of a natural product. correct incorrect

Biosynthetic pathways that link different biosynthetic precursors correct incorrect

Designing a novel biosynthetic pathway by combining part of one biosynthetic pathway with part of a second biosynthetic pathway. correct incorrect

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. Which of the following is an example of a super enzyme?

Non-ribosomal peptide synthases. correct incorrect

Esterases correct incorrect

Kinases correct incorrect

Proteases correct incorrect

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. Which of the following structures is crucial to the preparation of semi-synthetic penicillins?

Structure A correct incorrect

Structure B correct incorrect

Structure C correct incorrect

Structure D correct incorrect

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. Which kind of enzyme has been useful in the synthesis of macrocyclic lactams?

Thioesterase correct incorrect

Esterase correct incorrect

Kinase correct incorrect

Ligase correct incorrect

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. Which of the following compounds is a useful starting material for the semi-synthetic formation of artemisinin?

Acetyl coenzyme A correct incorrect

Farnesyl diphosphate correct incorrect

Amorpha-4,11-diene correct incorrect

Artemisinic acid correct incorrect