Chapter 14 Multiple Choice Questions

. Which of the following diagrams has the correct numbering system for fluoroquinolones?

. Which of the following was the first therapeutically useful quinolone antibaterial agent?

. Which of the following structures is ciprofloxacin?

. Which enzymes are the target for the quinolone antibacterial agents?

. Which amino acid residue in topoisomerases is responsible for the temporary splitting of DNA strands?

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Which region of the fluoroquinolone skeleton is involved in binding interactions with DNA in the ternary complex formed between DNA, toposiomerase and the drug?

. Which of the following fluoroquinolones is chiral?

. Which of the following structures would be a feasible intermediate for the synthesis of fluoroquinolones having antibacterial activity?

. Gatifloxacin has been synthesised using a strategy where an intramolecular cyclisation was carried out that involved nucleophilic substitution of an aryl halide.

Which of the structures (A-D) would be suitable as the staring material for this synthesis?

. The synthesis of clinafloxacin includes the following reaction.

Which of the substituents present in the starting material is likely to have the greatest influence over the regioselectiivity of the reaction?

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