Chapter 1 Multiple Choice Questions

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. Which of the following statements best describes a lead compound?

A compound that contains the element lead correct incorrect

A compound from the research laboratory that is chosen to go forward for preclinical and clinical trials correct incorrect

A molecule that shows some activity or property of interest and serves as the starting point for the development of a drug. correct incorrect

The first compound of a structural class of compounds to reach the market. correct incorrect

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. Identify the kind of interactions that are typically involved in binding a drug to the binding site of a protein.

predominantly van der Waals interactions correct incorrect

predominantly ionic bonds correct incorrect

predominantly hydrogen bonds correct incorrect

a combination of all of the above correct incorrect

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. Which of the following statements best describes an induced fit?

the process by which a binding site alters shape such that it is ready to accept a drug correct incorrect

the process by which a drug adopts the correct binding conformation before entering a binding site correct incorrect

the process by which binding of a drug to a binding site alters the shape of the binding site correct incorrect

the process by which a binding site alters the shape of the drug into the binding conformation before binding correct incorrect

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. Which of the following descriptions most accurately describes binding sites and binding regions?

a binding site is part of a binding region correct incorrect

a binding region is part of a binding site correct incorrect

a binding region is the same as a binding site correct incorrect

a binding region is on a drug whereas a binding site is on a macromolecular target correct incorrect

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. Which of the following terms is used to describe a drug that has the same effect on a receptor as the endogenous chemical messenger?

agonist correct incorrect

antagonist correct incorrect

partial agonist correct incorrect

inverse agonist correct incorrect

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. Which of the following statements best describes pharmacokinetics?

the study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution, metabolism and excretion. correct incorrect

the study of how drugs can be designed using molecular modelling based on drug's pharmacophore. correct incorrect

the study of how a drug interacts with its target binding site at the molecular level to produce a particular pharmacological effect. correct incorrect

the study of which functional groups are important to a drug's activity, and the identification of a pharmacophore. correct incorrect

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. What is meant by ADME in pharmacokinetics?

Affinity, dosage, marketing, efficacy correct incorrect

Absorption, distribution, metabolism, excretion correct incorrect

Agonism, dependence, mobility, efficiency correct incorrect

Antagonism, deficiency, mean, efflux correct incorrect

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. Which of the following is one of the rules in Lipinski's rule of five?

A molecular weight equal to 500 correct incorrect

No more than five hydrogen bond acceptor groups correct incorrect

No more than 10 hydrogen bond donor groups correct incorrect

A calculated logP value less than +5 correct incorrect

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. Which of the following statements is false regarding the blood brain barrier?

The walls of the capillaries supplying the brain have
tight fitting cells making it difficult for polar drugs
to leave the capillaries correct incorrect

The capillaries in the brain have a fatty coating making it more difficult for drugs to enter the brain correct incorrect

The walls of the capillaries supplying the brain are made up of several layers of cells, which act as a barrier to the release of drugs correct incorrect

Hydrophobic drugs pass through the blood brain barrier more easily than hydrophilic drugs correct incorrect

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. What term is used to signify a preparation that appears identical to the preparation of an active drug but which has no biological activity?

Dummy drug correct incorrect

Peptidomimetic correct incorrect

Placebo correct incorrect

Gazebo correct incorrect