Neuroscience 6e Chapter 13 Summary

Sound waves are transmitted via the external and middle ear to the cochlea of the inner ear, which exhibits a traveling wave when stimulated. For high-frequency sounds, the amplitude of the traveling wave reaches a maximum at the base of the cochlea; for low-frequency sounds, the traveling wave reaches a maximum at the apical end. The associated motions of the basilar membrane are transduced primarily by the inner hair cells, while the basilar membrane motion is itself actively modulated by the outer hair cells. Damage to the outer or middle ear results in conductive hearing loss, while hair cell damage results in a sensorineural hearing deficit. The tonotopic organization of the cochlea is retained at all levels of the central auditory system. Projections from the cochlea travel via the auditory nerve to the three main divisions of the cochlear nucleus. The targets of the cochlear nucleus neurons include the superior olivary complex and nuclei of the lateral lemniscus, where the binaural cues for sound localization are processed. The inferior colliculus, the target of nearly all of the auditory pathways in the lower brainstem, carries out important integrative functions, such as processing of sound frequencies and integration of the cues for localizing sound in space. The primary auditory cortex, which is also organized tonotopically, supports basic auditory functions, such as frequency discrimination and sound localization, and also plays an important role in processing of intraspecific communication sounds. Populations of neurons in belt areas of the auditory cortex, which have a less strict tonotopic organization, display activity patterns that correlate with speech intelligibility and that are strongly modulated by linguistic features and cognitive context. In the human brain, the major speech comprehension areas reside in the zone immediately adjacent to the auditory cortex, and motor-related activity can strongly modulate auditory cortical responses to vocalization-related auditory feedback, suggestive of a predictive sensorimotor mechanism.