Figure 3.17

The summary of the drug alteration of synaptic transmission is illustrated. The eleven-step process of the mechanism is as follows: Step 1: The drug acts as an NT precursor, as indicated by a positive sign. Step 2, The drug inhibits NT synthesis, as indicated by a negative sign. Step 3: The drug prevents NT storage in vesicles, as indicated by a negative sign. Step 4, The drug stimulates the release of NT, as indicated by a positive sign. Step 5: The drug inhibits the release of NT, as indicated by a negative sign. Step 6: The drug stimulates postsynaptic receptors, as indicated by a positive sign. Step 7, The drug blocks postsynaptic receptors, as indicated by a negative sign. Step 8: The drug stimulates auto receptors while inhibiting NT release, as indicated by a negative sign. Step 9, The drug blocks auto receptors; increases the release of NT, as indicated by a positive sign. Step 10: The drug inhibits NT degradation, as indicated by a positive sign. Step 11, The drug blocks reuptake, as indicated by a positive sign. Steps 1 to 5 and 8 to 9 take place within the channel. Steps 6 and 7 take place within the receptor. Steps 10 and 11 takes place within the synapse.

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