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Return to Biochemistry: The Molecular Basis of Life, Seventh International Edition Student Resources
Chapter 10 Review Quizzes
Aerobic Metabolism II: Electron Transport and Oxidative Phosphorylation
Quiz Content
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Obligate anaerobes have difficulty living in environments containing:
Oxygen
correct
incorrect
Nitrogen
correct
incorrect
Argon
correct
incorrect
Carbon dioxide
correct
incorrect
Water
correct
incorrect
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The mechanism of damage done by free radicals (now called reactive oxygen species) to both physiological systems and to mechanical substances is still not fully understood, but the danger posed is substantial. ROSs are implicated in nasty processes from polymerization of gasoline to formation of varnishes which clog carburetors and injectors to formations of plaque which may cause arteries. Producers of foodstuffs worry about ROSs causing premature spoilage of foods, and often include free radical scavengers. Even some fitness waters contain free radical scavengers. Examine a box of cereal and find the antioxidant labeled there:
Vitamin B
correct
incorrect
Riboflavin
correct
incorrect
Thiamine pyrophosphate
correct
incorrect
BHA (butylated hydroxyanisole) or its cousin BHT (butylated hydroxytoluene)
correct
incorrect
Benzene
correct
incorrect
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During the terrible winter fighting conditions on the Eastern Front in Europe during WWII, many soldiers froze to death. In order to maintain higher body temperatures, some armies are reported to have been issued pills of 2,4-dinitrophenol. While use of this uncoupler of oxidative phosphorylation may have resulted in higher temperatures, it might have caused eventual organ failure. Which organ?
Lungs
correct
incorrect
Liver
correct
incorrect
Kidneys
correct
incorrect
Heart
correct
incorrect
Pancreas
correct
incorrect
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Formation of ATP is increased by:
A high ratio of ATP to ADP
correct
incorrect
A high ratio of ADP to ATP
correct
incorrect
A high ratio of ATP to AMP
correct
incorrect
A high ratio of ATP to phosphate
correct
incorrect
A high ratio of ATP to glucose
correct
incorrect
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If not otherwise dangerous, uncouplers would make good diet aids because:
They don't take part in the ETC
correct
incorrect
They don't block any other reactions
correct
incorrect
They lower redox potential
correct
incorrect
They are very inexpensive
correct
incorrect
They allow protons to pass through the mitochondrial membrane without ATP synthesis
correct
incorrect
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Formation of ATP as a result of passage of electrons through the ETC is sometimes called oxidative phosphorylation because:
As substrates are reduced, ADP is converted to ATP
correct
incorrect
As ADP is phosphorylated, glucose is reduced in mitochondria
correct
incorrect
The endoplasmic reticulum becomes oxidized due to the relatively oxidative environment of the nucleus
correct
incorrect
As substrates are oxidized, ADP is phosphorylated to form ATP
correct
incorrect
Mitochondria are easily ignited
correct
incorrect
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Long known to be protective against scurvy, Vitamin C owes at least some of its value to the fact that it acts as an antioxidant. This means that vitamin C itself is:
An oxidizing agent
correct
incorrect
An acid
correct
incorrect
A base
correct
incorrect
A reducing agent
correct
incorrect
A blocker of the electron transport chain which results in the loss of a great many electrons
correct
incorrect
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Dentists often examine the mouths of patients for signs of acatalasemia. In this illness, hydrogen peroxide produced by bacteria may oxidize the Fe
+2
of hemoglobin to Fe
+3
, forming methemoglobin which does not carry oxygen as well. Ordinarily, we are protected from this danger by the enzyme:
Glutathione peroxidase
correct
incorrect
Superoxide dismutase
correct
incorrect
Catalase
correct
incorrect
Transaminase
correct
incorrect
Glucose-6-phosphate dehydrogenase
correct
incorrect
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Both cyanide ion and hydrogen cyanide gas are highly toxic, blocking the movement of electrons through the ETC. Victims of cyanide poisoning often display rictus, a gaping grimace as though they were trying to take a bite out of the air. One reason why they might do this is:
The body senses that too much oxygen is available and compensates by hyperventilating
correct
incorrect
The body senses that too little ATP is available
correct
incorrect
Excess pyruvic acid accumulates and shuts down glycolysis by a feedback mechanism
correct
incorrect
Excess carbon dioxide results in a respiratory acidosis, with plasma pH falling below 7.35 and shutting down the proton pumps
correct
incorrect
Lack of an acceptor for electrons at the end of the ETC produces the same symptoms as oxygen deficiency
correct
incorrect
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Reactive oxygen species such as hydrogen peroxide and superoxide radicals may be generated by scavenger cells and used to destroy unwanted invaders or metabolic fragments. The ROS are generated by a process called the:
Oxidative burst
correct
incorrect
Photosynthetic burst
correct
incorrect
Thylakoid disk
correct
incorrect
Charge coupled inducer
correct
incorrect
Respiratory burst
correct
incorrect
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Among the important antioxidant molecules taken in with our food are:
α-Tocopherol, β-carotene, and ascorbic acid
correct
incorrect
Hydrogen peroxide and sodium chloride
correct
incorrect
Hypochlorous acid and nitric oxide
correct
incorrect
Nitroglycerine and FAD
correct
incorrect
Iron (III) chloride and lead (II) nitrate
correct
incorrect
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The endoplasmic reticulum usually functions in an oxidative environment. In ER stress, low oxygen concentration results in inability of the ER to properly facilitate protein folding. Which of the following reactions is likely to be compromised?
Ligase enzymes are unlikely to be able to link amino acids into peptides
correct
incorrect
Ligases are not able to form polynucleotides
correct
incorrect
Cysteine molecules between regions of the protein are not joined by disulfide bonds
correct
incorrect
Amino acids are unable to lose protons
correct
incorrect
Proteins gain too many protons due to the acidic environment
correct
incorrect
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Persons who suffer angina (chest pain associated with cardiac problems) sometimes place a small pill containing nitroglycerine under their tongue. As the nitroglycerine decomposes, a small amount of a substance is produced which lowers blood pressure, relieving the angina. The substance released by decomposing nitroglycerine is an important signaling molecule which helps to regulate blood pressure. Which of the following is the best candidate?
NO
correct
incorrect
HCN
correct
incorrect
H
2
S
correct
incorrect
H
2
O
correct
incorrect
CO
2
correct
incorrect
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Erythrocytes are fragile and may be damaged by illnesses such as hemolytic anemia, resulting in dark-colored urine. Normally, the erythrocytes are protected by:
Reduced glutathione
correct
incorrect
Reduced cystine
correct
incorrect
Oxidized glutathione
correct
incorrect
Hydrogen peroxide
correct
incorrect
Superoxide dismutase
correct
incorrect
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While selenium may be an important part of some enzyme systems, large quantities can be toxic. Both Marco Polo in his historic travels to China and present-day ranchers in Western Nebraska and Eastern Wyoming suffered livestock losses due to toxic levels of selenium in plants eaten by the animals. One route of absorption of selenium might be its incorporation in amino acids in the plant, and later release of the selenium upon digestion and metabolism of the amino acids. Which amino acid might be a good candidate to carry the selenium?
Glycine
correct
incorrect
Cysteine
correct
incorrect
Tryptophan
correct
incorrect
Alanine
correct
incorrect
Lysine
correct
incorrect
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The interior of the inner mitochondrial membrane is relatively impermeable to ionic substances because:
The membrane itself is ionic
correct
incorrect
The membrane is relatively polar
correct
incorrect
The outer portions of the membrane nearest the cytoplasm or mitochondrial matrix are relatively polar
correct
incorrect
The inside of the membrane is filled with water
correct
incorrect
The inside portion of the membrane is a lipid bilayer and relatively nonpolar
correct
incorrect
*
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The ATP synthase complex is often called the F
1
Fo ATP synthase. This refers to the fact that the synthase enzyme is composed of:
A shaft or stator connecting an Fo motor and an F1 ATP generator
correct
incorrect
An Fo shaft connecting a stator motor and an F1 ATP generator
correct
incorrect
An F1 proton-powered motor and an Fo ATP generator
correct
incorrect
An Fo motor and an F1 ATP generator connected to a stator which can drive a small set of gears
correct
incorrect
A polynucleotide gel connected to the ER
correct
incorrect
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Glucose may be oxidized by a combination of several pathways and cycles. If the oxidation of glucose relied on glycolysis and the TCA cycle, how many moles of ATP could be produced by complete oxidation of a mole of glucose-6-phosphate?
2
correct
incorrect
15
correct
incorrect
48
correct
incorrect
22
correct
incorrect
30
correct
incorrect
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Depriving muscle tissue of oxygen is a dangerous process known as:
Paranoia
correct
incorrect
Hyperoxia
correct
incorrect
Reduction
correct
incorrect
Ischemia
correct
incorrect
Hypercatalasemia
correct
incorrect
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A single reduced molecule or NADH is considered to be equivalent in energy to 2.5 ATP molecules. Oxidation of a mole of FADH
2
yields 1.5 ATP. In chemical terms, this would mean that:
FADH
2
has a higher standard oxidation potential than NADH
correct
incorrect
FADH
2
has a higher standard oxidation potential than NAD
+
correct
incorrect
NADH
2
has a higher standard oxidation potential than FADH
2
correct
incorrect
FADH
2
has a higher standard oxidation potential than NADH
correct
incorrect
NADH has a higher standard oxidation potential than FADH
2
correct
incorrect
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Mitchell's chemiosmotic theory suggested that a high concentration of protons outside the mitochondrial membrane:
Reduced the oxidation potential
correct
incorrect
Made the interior of the membrane highly acidic
correct
incorrect
Caused the exterior of the membrane to become highly basic
correct
incorrect
Generated a voltage and a protonmotive force which helped drive the ATP synthase
correct
incorrect
Generated a low electrical potential and proton equalization which caused protons to exit the mitochondria
correct
incorrect
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It's likely that your cereal boxes note on their labels that the contents include a small amount of BHT or BHA (butylated hydroxyanisole). Both BHT and BHA are antioxidants included not to make you healthy, but to make you happier than you would be if the long chain fatty acids in your food become rancid. They become rancid by oxidative processes which attack double bonds in unsaturated acids. The result would be unpleasant because:
The shorter-chain acids produced by oxidation would be poisonous and inedible
correct
incorrect
The shorter-chain acids produced by oxidation would be volatile and smelly
correct
incorrect
Long chain unsaturated fatty acids are essential for health
correct
incorrect
People would spontaneously combust
correct
incorrect
The antioxidants would have no other function
correct
incorrect
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Which is the correct order of decreasing size?
Eukaryotic cells, ATP synthase, mitochondria
correct
incorrect
Mitochondria, eukaryotic cells, ATP synthase
correct
incorrect
Eukaryotic cells, mitochondria, ATP synthase
correct
incorrect
ATP synthase, mitochondria, eukaryotic cell
correct
incorrect
ATP synthase, eukaryotic cells, mitochondria
correct
incorrect
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