Section 6.4 Quiz

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. Identify true statements about major histocompatibility complex (MHC) molecules.

MHC Class I and Class II molecules differ in their composition. correct incorrect

Peptides derived through phagocytosis are presented via MHC class I molecules. correct incorrect

MHC Class II molecules are made up of three subunits. correct incorrect

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. The α₃ domain and β₂-microglobulin provides underlying structural support to the peptide-binding groove of MHC class I molecules.

True correct incorrect

False correct incorrect

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. The peptide-binding groove of MHC class I molecules interacts and binds to the antigen peptide along its full length.

True correct incorrect

False correct incorrect

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. Peptides generated by the destruction of intracellular cytosolic proteins are presented to T-cells via MHC Class II molecules.

True correct incorrect

False correct incorrect

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. Which of the following statements are true about the structure of MHC class I molecules?

The peptide-binding groove of MHC Class I molecules is formed through the interface of the α and β chains. correct incorrect

The α₁ and α₂ domains of the α subunit provide the structural features of the peptide-binding groove. correct incorrect

The MHC Class I molecule interacts with the side chains found in the bound peptide. correct incorrect

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. The soluble protein that provides structural support to the protein-binding groove of MHC Class I molecules, along with the α₃ domain, using immunoglobulin-like domains is the _____.

α₁ chain correct incorrect

CD4 coreceptor correct incorrect

CD8 coreceptor correct incorrect

β₂-microglobulin correct incorrect