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Return to Immunology Student Resources
Section 6.3 Quiz
*
not completed
.
Exonucleases can trim the P nucleotides left in the overhang region of the opened end of the gene segment, whereas _____ can add N nucleotides to the ends of each gene segment without the requirement of a template strand.
terminal deoxynucleotidyl transferase
correct
incorrect
immunoproteasome
correct
incorrect
Calnexin
correct
incorrect
Endoplasmic reticulum aminopeptidase
correct
incorrect
*
not completed
.
In the recombination events that enhance the diversity of T-cell receptors, the removal of P nucleotides and addition of N nucleotides is random.
False
correct
incorrect
True
correct
incorrect
*
not completed
.
Productive rearrangements result in the production of a functional receptor subunit, whereas unproductive rearrangements alter the production of the subunit and result in a nonfunctional T-cell receptor.
True
correct
incorrect
False
correct
incorrect
*
not completed
.
Why does a T cell activate apoptosis when unproductive rearrangements are made at all the α andβ loci?
Because such a T cell can strongly bind to MHC-peptide complexes
correct
incorrect
Because such a T cell can cause autoimmune disorders
correct
incorrect
Because a T cell is nonfunctional without a receptor
correct
incorrect
Because a T cell with productive rearrangements at γ and δ loci instead is nonfunctional
correct
incorrect
*
not completed
.
Which of the following can alter the reading frame of the recombined locus that is used to produce a protein product to function as a T-cell receptor subunit?
Notch signaling pathway
correct
incorrect
Addition or removal of N and P nucleotides
correct
incorrect
Activation of the transcription factor FOXP3
correct
incorrect
*
not completed
.
Which of the following is likely to happen if T cells with a self-recognizing receptor escape the thymus?
Deficiency of B cells
correct
incorrect
Development of peripheral tolerance
correct
incorrect
Lack of production of insulin
correct
incorrect
Development of autoimmune disorders
correct
incorrect
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