Section 6.3 Quiz

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. Exonucleases can trim the P nucleotides left in the overhang region of the opened end of the gene segment, whereas _____ can add N nucleotides to the ends of each gene segment without the requirement of a template strand.

terminal deoxynucleotidyl transferase correct incorrect

immunoproteasome correct incorrect

Calnexin correct incorrect

Endoplasmic reticulum aminopeptidase correct incorrect

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. In the recombination events that enhance the diversity of T-cell receptors, the removal of P nucleotides and addition of N nucleotides is random.

False correct incorrect

True correct incorrect

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. Productive rearrangements result in the production of a functional receptor subunit, whereas unproductive rearrangements alter the production of the subunit and result in a nonfunctional T-cell receptor.

True correct incorrect

False correct incorrect

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. Why does a T cell activate apoptosis when unproductive rearrangements are made at all the α andβ loci?

Because such a T cell can strongly bind to MHC-peptide complexes correct incorrect

Because such a T cell can cause autoimmune disorders correct incorrect

Because a T cell is nonfunctional without a receptor correct incorrect

Because a T cell with productive rearrangements at γ and δ loci instead is nonfunctional correct incorrect

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. Which of the following can alter the reading frame of the recombined locus that is used to produce a protein product to function as a T-cell receptor subunit?

Notch signaling pathway correct incorrect

Addition or removal of N and P nucleotides correct incorrect

Activation of the transcription factor FOXP3 correct incorrect

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. Which of the following is likely to happen if T cells with a self-recognizing receptor escape the thymus?

Deficiency of B cells correct incorrect

Development of peripheral tolerance correct incorrect

Lack of production of insulin correct incorrect

Development of autoimmune disorders correct incorrect