Section 6.1-6.2 Quiz

. MHC molecule diversity is generated through recombination events.

True

False

. Identify the major function of the T-cell receptor.

Recognizing a specific MHC-peptide complex

Processing and presenting antigens

Binding strongly to self-molecules

Driving the innate immune system response

. Which of the following are true about the hypervariable regions of T-cell receptors?

They are found at the junctions of V, D, and J segments.

They prevent the engagement of an immunoglobulin with its specific antigen.

They remain constant regardless of the mechanisms of somatic recombination.

. Identify a true statement about γδ receptors of T cells.

They can recognize their antigen without the presence of an MHC molecule.

They have to recognize a peptide antigen.

They only recognize peptide antigens presented by MHC molecules.

They lack the ability to recognize lipid as an antigen.

. Activated _____ T cells become cytotoxic T cells that target intracellular pathogens, while activated CD4 T cells become helper T cells (T_H).

CD8

CD28

CD45

CD4

. Identify a true statement about the T-cell receptor signaling complex.

T cells use the CD4 or CD8 coreceptor to initiate signaling, along with the CD3 complex.

The two polypeptide chains of the T-cell receptor initiate intracellular signaling events on their own.

The two polypeptide chains of the T-cell receptor have a cytoplasmic domain that initiates transmission of an extracellular signal to the nucleus.

T cells use the CD28 coreceptor, along with CTLA4, to initiate signaling.

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