Section 5.8 Quiz

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. Identify the reason for extensive T-cell receptor diversity.

Lack of overexpression of Notch1 correct incorrect

Lack of allelic exclusion correct incorrect

Somatic recombination correct incorrect

Secretion of IL-7 by developing thymocytes correct incorrect

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. The majority of circulating T cells express _____.

neither αβnor γδT-cell receptor correct incorrect

a γδT-cell receptor correct incorrect

an αβT-cell receptor correct incorrect

both αβand γδT-cell receptor correct incorrect

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. T cells in the body that express a γδ T-cell receptor reside mainly within the _____.

thymic medulla correct incorrect

gut mucosa correct incorrect

bone marrow correct incorrect

thymic cortex correct incorrect

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. Why is the diversity of variable regions in T cells extensive?

Because of removal rather than addition of P and N nucleotides during recombination correct incorrect

Because of repackaging of the β-chain locus into tightly packed chromatin correct incorrect

Because a large number of variable segments of D subunits rather than V and J subunits are present correct incorrect

Because recombination of variable segments is random correct incorrect

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. In the T-cell receptor one properly recombined subunit needs to associate with another randomly recombined subunit.

True correct incorrect

False correct incorrect

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. Junctional diversity decreases the number of different T-cell receptors to 2.3 × 107.

True correct incorrect

False correct incorrect

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. Which of the following controls gene arrangement of T-cell receptor loci?

Allelic exclusion correct incorrect

Somatic recombination correct incorrect

Notch signaling pathway correct incorrect

MHC restriction correct incorrect

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. An αβ T-cell receptor, when activated, can differentiate into effector T cells that activate a range of adaptive immune responses.

True correct incorrect

False correct incorrect

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. Identify a true statement about circulating T cells.

They recognize compounds of mevalonate synthesis of different microorganisms. correct incorrect

They are responsible for the pattern recognition receptor of the innate immune system. correct incorrect

They are responsible for MHC restriction. correct incorrect

They play a vital role in adaptive immune response. correct incorrect

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. Identify the type of cells that activate a range of other innate or adaptive immune cells, including macrophages, neutrophils, and B cells.

Pre-T cells correct incorrect

Intraepithelial lymphocytes correct incorrect

Effector T cells correct incorrect

Thymic epithelial cells correct incorrect