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Return to Immunology Student Resources
Section 5.7 Quiz
*
not completed
.
Double-positive (DP) thymocytes that have passed the checkpoints that occur during somatic recombination are tested by antigen-presenting cells (APCs) or _____ for the affinity of their T-cell receptor for MHC class I or II molecules presenting antigen.
natural killer cells
correct
incorrect
macrophages
correct
incorrect
double-negative thymocytes
correct
incorrect
cortical thymic epithelial cells
correct
incorrect
*
not completed
.
Which of the following forms the basis of the selection process of thymocytes within the thymic cortex?
The secretion of the RAG1 and RAG2 proteins
correct
incorrect
The affinity of the T-cell receptor for the MHC–peptide complexes
correct
incorrect
The ability to interact with an MHC class I molecule rather than an MHC class II molecule
correct
incorrect
The ability to express both CD4 and CD8 coreceptors
correct
incorrect
*
not completed
.
Most cells that have passed through the α and βcheckpoints undergo positive selection and are circulated in the body.
True
correct
incorrect
False
correct
incorrect
*
not completed
.
Identify a true statement about the role of dendritic cells in T-cell development.
They are completely responsible for the negative selection of CD8+ thymocytes within the thymic medulla.
correct
incorrect
They allow for positive selection of CD4+ thymocytes that bear a T-cell receptor that interacts too strongly with MHC molecules.
correct
incorrect
They remove thymocytes that lack functional coreceptors.
correct
incorrect
They present tissue-specific antigens via MHC class II antigen presentation.
correct
incorrect
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