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Return to Immunology Student Resources
Section 5.5-5.6 Quiz
*
not completed
.
Identify possible opportunities for a productive β-chain rearrangement.
β-chain D segment rearranging with a β2 VJ segment (V2J2)
correct
incorrect
β-chain D segment rearranging with a β1 VJ segment (V1J1)
correct
incorrect
β-chain V segment rearranging with a β1 DJ segment (D1J1)
correct
incorrect
*
not completed
.
Recombination of the α-chain locus occurs before the β-chain checkpoint has been passed.
True
correct
incorrect
False
correct
incorrect
*
not completed
.
Identify the true statement about the pre-T α chain (pTα) in the context of T-cell development.
It prevents any downstream signaling upon T-cell receptor engagement.
correct
incorrect
It assembles with the rearranged γδ chain.
correct
incorrect
It assembles with the CD3 complex and ensures that a functioning T-cell receptor can be formed later.
correct
incorrect
*
not completed
.
What happens to the large number of thymocytes that do not pass the α- and β-chain checkpoints?
They begin to express the coreceptors CD4 and CD8 and become double-positive thymocytes.
correct
incorrect
They form the pre-T α chain complex.
correct
incorrect
They are programmed to become pre-T cells.
correct
incorrect
They are programmed for cellular death and removal by resident macrophages.
correct
incorrect
*
not completed
.
Rearrangement of the α chain must be tested to ensure that the chain does not become a subunit of the T-cell receptor.
True
correct
incorrect
False
correct
incorrect
*
not completed
.
The α chain is tested in the endoplasmic reticulum membrane.
True
correct
incorrect
False
correct
incorrect
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