Section 5.5-5.6 Quiz - Immunology Student Resources

. Identify possible opportunities for a productive β-chain rearrangement.

β-chain D segment rearranging with a β2 VJ segment (V2J2)

β-chain D segment rearranging with a β1 VJ segment (V1J1)

β-chain V segment rearranging with a β1 DJ segment (D1J1)

. Recombination of the α-chain locus occurs before the β-chain checkpoint has been passed.

True

False

. Identify the true statement about the pre-T α chain (pTα) in the context of T-cell development.

It prevents any downstream signaling upon T-cell receptor engagement.

It assembles with the rearranged γδ chain.

It assembles with the CD3 complex and ensures that a functioning T-cell receptor can be formed later.

. What happens to the large number of thymocytes that do not pass the α- and β-chain checkpoints?

They begin to express the coreceptors CD4 and CD8 and become double-positive thymocytes.

They form the pre-T α chain complex.

They are programmed to become pre-T cells.

They are programmed for cellular death and removal by resident macrophages.

. Rearrangement of the α chain must be tested to ensure that the chain does not become a subunit of the T-cell receptor.

True

False

. The α chain is tested in the endoplasmic reticulum membrane.

True

False