Section 5.4 Quiz

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. Through which of the following processes do thymic epithelial cells promote somatic recombination of T-cell receptor genes?

Deactivation of Notch1 correct incorrect

Deactivation of the transcription factor FOXP3 correct incorrect

Secretion of the cytokine IL-7 correct incorrect

Secretion of the protein thymic stromal lymphopoietin (TSLP) correct incorrect

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. The primary goal of the developmental stages that thymocytes go through is to produce a population of T cells with a diverse array of T-cell receptors that recognize foreign antigen in the content of MHC.

True correct incorrect

False correct incorrect

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. Which of the following is the basis for the terms used to describe the thymocyte at each developmental stage?

The activation or deactivation of transcription factor FOXP3 (forkhead box P3) correct incorrect

The presence or absence of the protein Notch correct incorrect

The secretion or lack of secretion of cytokine signaling molecules correct incorrect

The presence or absence of T-cell coreceptor components on its surface correct incorrect

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. Which of the following is true of a thymocyte that becomes a double-positive thymocyte?

Only coreceptor CD8 is expressed by the developing T-cell. correct incorrect

Both coreceptors (CD4 and CD8) are present on the surface of the developing T-cell. correct incorrect

Only coreceptor CD4 is expressed by the developing T-cell. correct incorrect

Neither coreceptor (CD4 or CD8) is present on the surface of the developing T-cell. correct incorrect

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. During T-cell development, mouse thymocytes are referred to as _____ cells when the cells have gone through somatic recombination of their β chain and and are active in β chain allelic exclusion .

DN1 correct incorrect

DN3 correct incorrect

DN4 correct incorrect

DN2 correct incorrect

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. Which of the following is NOT a key checkpoint that a thymocyte must pass to continue development and become a functional naïve T cell?

Checkpoint of the β subunit of the T-cell receptor correct incorrect

Checkpoint of the α subunit of the T-cell receptor correct incorrect

Checkpoint of the γ subunit of the T-cell receptor correct incorrect

Checkpoint of the γδ subunit of the T-cell receptor correct incorrect

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. Which of the following can a thymocyte that has properly gone through development express?

Only an γδ T-cell receptor correct incorrect

Either an αβ T-cell receptor or a γδ T-cell receptor correct incorrect

Only an αβ T-cell receptor correct incorrect

Both αβ T-cell receptor and γδ T-cell receptor correct incorrect

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. Human thymocytes are similar to mouse thymocytes in regard to the cell-surface molecules present during the developmental process

True correct incorrect

False correct incorrect

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. Adults have a large quantity of γδ T cells.

True correct incorrect

False correct incorrect