Chapter 6 Vocabulary Quiz

. Gene family refers to genes present within an organism that express isotypes of the same biochemical function.

. The presence of multiple alleles within a population that encode for a particular gene product/isotype is referred to as genetic _____.

. Three loops of the variable regions of the T-cell receptor subunits or the heavy and light chains of immunoglobulins that have the most diverse differences are referred to as groove regions.

. The domain within an MHC molecule that binds to a peptide to present the bound peptide to a T-cell receptor is referred to as a peptide-binding groove.

. Genetic recombination at the immunoglobulin and T-cell receptor loci that creates a gene that can produce a functional subunit is referred to as _____ rearrangement.

. Genetic recombination at the immunoglobulin and T-cell receptor loci that creates a gene that cannot produce a functional subunit is referred to as _____ rearrangement.

. Promiscuous binding specificity refers to the ability of a single MHC molecule to bind to a single specific peptide in its peptide-binding groove.

. Which of the following is a membrane-bound endoplasmic reticulum (ER) chaperone that aids in folding of proteins in the secretory pathway?

. A protein complex within the endoplasmic reticulum (ER) that assists in moving intracellular peptides into the peptide-binding groove of MHC class I molecules is referred to as peptide-loading complex.

. Which of the following is an endoplasmic reticulum protein responsible for peptide loading and peptide exchange on MHC class I molecules?

. Which of the following is an endoplasmic reticulum chaperone that functions in the peptide-loading complex to promote proper folding of MHC class I molecules loaded with peptide?

. The multi-subunit enzyme complex that cleaves intracellular cytosolic proteins into peptides for presentation on MHC class I molecules or removal of damaged or abnormal proteins is known as the calreticulin.

. Proteasome complexes with 11S and β subunits that promote digestion of proteins into peptides of 8 to 10 amino acids in length for better presentation on MHC class I molecules is called immunoproteasome.

. Which of the following carries proteasome-derived peptides into the ER where they can interact with MHC class I molecules?

. Which of the following is a protease located in the ER lumen that trims the N-terminus of peptides bound to MHC class I molecules to bind peptides more tightly to the peptide-binding groove?

. Which of the following is a protein in the secretory pathway that binds to MHC class II molecules and blocks the peptide-binding groove from binding to intracellular peptides transported into the ER via TAP?

. A peptide produced upon digestion of the invariant chain that remains bound to MHC class II molecules until exchange with extracellular peptides generated during phagocytosis is called CLIP.

. Which of the following refers to an MHC class II molecule that functions in promoting peptide exchange of class-II associated invariant chain peptide (CLIP) with extracellular peptides generated by phagocytosis?

. The process by which endocytosed proteins are transported into the cytosol for cross-presentation is called cytosolic diversion

. Various protein products that have functional and structural similarities within an organism are referred to as _____.

. The protein product of a particular allele of a gene is referred to as _____.

. Expressed isotypes of all alleles of a gene family within an individual are referred to as _____.

. The sequence of amino acids of a peptide that are essential for interaction with an MHC molecule is known as peptide-binding motif.

. Residues of a peptide bound to an MHC molecule that are essential in interacting with the peptide-binding groove are referred to as anchor residues.

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