Chapter 5 Vocabulary Quiz

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. Developing immature T cells present in the thymus are referred to as _____.

thymic epithelial cells correct incorrect

thymocytes correct incorrect

thymic corpuscles correct incorrect

macrophages correct incorrect

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. Which of the following terms refers to a developing thymocyte within the thymus that does not express either T-cell coreceptor (CD4 or CD8)?

Double-negative thymocyte correct incorrect

Single-positive thymocyte correct incorrect

Double-positive thymocyte correct incorrect

αβ T cell correct incorrect

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. Which of the following terms refers to a developing thymocyte within the thymus that expresses both T-cell coreceptors (CD4 or CD8)?

Single-positive thymocyte correct incorrect

Double-positive thymocyte correct incorrect

γδ T cell correct incorrect

Double-negative thymocyte correct incorrect

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. A developing thymocyte that has undergone lineage commitment and expresses only a single coreceptor is referred to as a(n) _____-_____ thymocyte.

double-negative correct incorrect

single-positive correct incorrect

single-negative correct incorrect

double-positive correct incorrect

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. Which of the following terms refers to thymocytes that have entered the thymus?

Double-negative 2 (DN2) thymocytes correct incorrect

Double-negative 4 (DN4) thymocytes correct incorrect

Double-negative 1 (DN1) thymocytes correct incorrect

Double-negative 3 (DN3) thymocytes correct incorrect

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. Which of the following terms refers to thymocytes that have committed to T-cell development?

Double-negative 1 (DN1) thymocytes correct incorrect

Double-negative 2 (DN2) thymocytes correct incorrect

Double-negative 3 (DN3) thymocytes correct incorrect

Double-negative 4 (DN4) thymocytes correct incorrect

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. Which of the following terms refers to thymocytes that have finished β-chain rearrangement and are active in β-chain allelic exclusion and proliferation to engage in α-chain rearrangement?

Double-negative 2 (DN2) thymocytes correct incorrect

Double-negative 3 (DN3) thymocytes correct incorrect

Double-negative 4 (DN4) thymocytes correct incorrect

Double-negative 1 (DN1) thymocytes correct incorrect

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. Which of the following terms refers to thymocytes that are active in α-chain rearrangement?

Double-negative 1 (DN1) thymocytes correct incorrect

Double-negative 2 (DN2) thymocytes correct incorrect

Double-negative 4 (DN4) thymocytes correct incorrect

Double-negative 3 (DN3) thymocytes correct incorrect

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. Which of the following is a protein expressed in thymocytes that has finished β-chain rearrangement and acts as a surrogate to test proper expression and action of the recombined β chain?

Notch1 correct incorrect

RAG1 correct incorrect

Thymic stromal lymphopoietin (TSLP) correct incorrect

Pre-T α chain (pTα) correct incorrect

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. Which of the following refers to thymocytes that have successfully passed the β-chain checkpoint?

Double-positive thymocytes correct incorrect

Single-positive thymocytes correct incorrect

Pre-T cells correct incorrect

DN4 cells correct incorrect

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. Which of the following terms refers to the inactivation of somatic recombination and active chromatin remodeling in order to prevent further recombination of specific loci of adaptive immune receptors?

MHC restriction correct incorrect

Allelic exclusion correct incorrect

Lineage commitment correct incorrect

Central tolerance correct incorrect

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. Which of the following refers to the process by which developing double-positive thymocytes switch to the expression of a single coreceptor and become single-positive thymocytes?

Allelic exclusion correct incorrect

Central tolerance correct incorrect

MHC restriction correct incorrect

Lineage commitment correct incorrect

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. The selection process driven by a recombined and expressed cell-surface T-cell receptor that can only interact with a specific self-MHC molecule is referred to as MHC _____.

restriction correct incorrect

recombination correct incorrect

recognition correct incorrect

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. Which of the following refers to the negative selection processes that occur in primary lymphoid tissues that are responsible for the removal of self-reactive lymphocytes?

Peripheral tolerance correct incorrect

Central tolerance correct incorrect

MHC restriction correct incorrect

Allelic exclusion correct incorrect

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. The negative selection/inactivation processes that occur in peripheral tissues to prevent the activation of self-reactive lymphocytes that have escaped negative selection in their primary lymphoid tissues are referred to as _____ tolerance.

peripheral correct incorrect

central correct incorrect