Case Study Quiz: Type I Diabetes

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. Which of the following answers describes why type 1 diabetes defined as an autoimmune disorder?

Because of the presence of T cells that are autoreactive to insulin correct incorrect

Because of the absence of anti-insulin autoantibodies correct incorrect

Because the autoimmune regulator allows epithelial cells to express genes not normally expressed by epithelial cells of the thymus correct incorrect

Because peripheral T cells and thymocytes within the thymic medulla contain an autoreactive β chain correct incorrect

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. Blood tests of an individual with type 1 diabetes reveals the presence of anti-_____ autoantibodies.

adrenaline correct incorrect

insulin correct incorrect

glucagon correct incorrect

somatostatin correct incorrect

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. In Deion's story, which of the following processes within thymocyte development is likely faulty and, hence, allowed the production of autoreactive T cells within the patient?

Negative selection of CD4+ thymocytes that bear a T-cell receptor that interacts too strongly with an MHC class II–tissue-specific antigen peptide correct incorrect

Secretion of interleukin (IL-7) by thymic epithelial cells in the thymic cortex and medulla correct incorrect

Interaction between Notch1 on the lymphoid progenitor and Notch ligand on the thymic epithelial cells correct incorrect

Repackaging of the β-chain locus into tightly condensed chromatin correct incorrect

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. In Deion's story, the defect that led to the production of autoreactive T cells occurred in the _____, where thymic epithelial cells, as well as dendritic cells, present self-peptides to allow for a means of negative selection that drives central tolerance.

connective tissue capsule correct incorrect

thymic cortex correct incorrect

bone marrow correct incorrect

thymic medulla correct incorrect