Case Study Quiz: Bare Lymphocyte Syndrome

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. If a white blood cell (WBC) analysis by flow cytometry reveals a lack of MHC class I molecules, which of the following is the most likely diagnosis?

DiGeorge syndrome correct incorrect

Type 1 diabetes correct incorrect

Bare lymphocyte syndrome I correct incorrect

Rheumatoid arthritis correct incorrect

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. Identify the common symptom associated with bare lymphocyte syndrome.

Chronic skin lesions correct incorrect

Hyperactivity correct incorrect

Low body temperature correct incorrect

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. Bare lymphocyte syndrome I is associated with a lack of _____.

CD4 T cells correct incorrect

MHC class I molecules correct incorrect

thymic epithelial cells correct incorrect

B cells correct incorrect

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. Which of the following is a white blood cell (WBC) analysis by flow cytometry likely to reveal in a patient with bare lymphocyte syndrome I?

Very low CD8 T-cell count correct incorrect

High count of self-reactive T cells correct incorrect

High count of all types of T cells correct incorrect

Very low count of B cells correct incorrect

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. In patients with bare lymphocyte syndrome I, which of the following could best explain the link between the very low CD8 T-cell count and a lack of MHC class I molecules on the cell surface?

There exists no mechanism to promote tolerance to CD8 T cells. correct incorrect

A subset of CD8 T cells express a self-reactive T-cell receptor with a high avidity to MHC class I proteins. correct incorrect

CD8 T cells interact with antigen presented via MHC class II molecules but not MHC class I molecules. correct incorrect

MHC class I molecules present peptides to CD8 T cells. correct incorrect