Chapter 6 Self-test questions

Pharmacogenetics and Personalised Medicine
. Before prescribing particular drugs, economic models show that screening for genetic variants may be more cost-effective in some countries than others?

. The liver is a major site of drug and pro-drug metabolism.

. The BCR-ABL fusion gene is a useful marker for the management of breast, ovarian and colorectal cancer?

. Oncogenes encode proteins that control cell proliferation and/or apoptosis. Oncogene mutations drive carcinogenesis.

. Which gene product is an ion channel and the target for the drug called ivacaftor?

. Which is the single best term to describe the effects of a drug on its target cell or tissue?

. Which is the single best term to describe how the systems of the body handle a drug once it has been ingested or administered?

. Which is the best term to describe the analysis of genome-wide variation on the clinical benefit and adverse effects of prescribed drugs?

Back to top