* not completed

. What is the molecular basis of action of Pt(II) chemotherapy agents?

A stable complex is formed between the DNA and Pt(II); the DNA helix bends and unwinds partially. correct incorrect

A stable complex is formed between the DNA and Pt(II); the DNA is reduced by the Pt(II) complex. correct incorrect

A stable complex is formed between the DNA and Pt(II); the DNA is oxidized by the Pt(II) complex. correct incorrect

* not completed

. The complexes of which transition metal are commonly used as anti-arthritis drugs?

Pt correct incorrect

Fe correct incorrect

Au correct incorrect

* not completed

. What is the basic of the activity of bismuth(III) complexes in the treatment of gastric ulcers?

The Bi(III) complexes increase the gastric pH making the gastric environment hostile to the bacteria causing the ulcer. correct incorrect

The Bi(III) complexes are able to bind to the bacterial DNA and disrupt the reproduction of the pathogens. correct incorrect

Bi(III) can form strong bonds with many donor atoms found in the protein structure and can interfere with binding of other metals to the bacterial proteins inhibiting their activity. correct incorrect

* not completed

. What is "lithium therapy" for bipolar disorders?

It is an aqueous solution of LiCl or Li₂CO₃ correct incorrect

It is a pill with Li silicate as an active ingredient. correct incorrect

It is an injection of Li-containing phosphate buffer. correct incorrect

* not completed

. The most important anti-malaria drugs belong to the 'quinine' family. Which organometallic moiety is attached to the quinine backbone in modern anti-malaria drugs?

Fe(CO)₄ correct incorrect

Cp₂Fe correct incorrect

CpFe(CO) correct incorrect

* not completed

. Cyclams are _____________ and their derivatives are used as __________ in medicine.

macrocyclic ligands; anti-HIV agents correct incorrect

oligomers; contrast reagents correct incorrect

peptide-based ligands; anticancer drugs correct incorrect

* not completed

. CO is a very poisonous gas. However, recently it has been found that this gas can play an important role in biological systems. Which role is that?

CO can act as a stimulant. correct incorrect

CO can have important signaling roles. correct incorrect

In small doses CO can act as a mild anesthetic. correct incorrect

* not completed

. The treatment of iron overload by chelation therapy involves sequestration of iron based on:

transferrins correct incorrect

siderophores correct incorrect

ferritins correct incorrect

* not completed

. On which two metallic elements are imaging agents most commonly based?

Gadolinium and technetium. correct incorrect

Iron and gallium correct incorrect

Germanium and thallium. correct incorrect

* not completed

. The complexes of which d-block element are getting importance in anti-cancer therapy?

Zr correct incorrect

Ru correct incorrect

Pd correct incorrect