Chapter 8 Multiple choice Questions

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. Insulin is made in which of the following ways?

As a preproinsulin protein which is modified as it is moved through the cell to the plasma membrane. correct incorrect

From the products of the expression of two separate genes. correct incorrect

From the products of genes expressed in the nucleus and mitochondria. correct incorrect

As a preproinsulin protein which is modified in the nucleus. correct incorrect

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. The structure of active insulin is which of the following?

A homodimer held together by cystine bridges. correct incorrect

A heterodimer held together by cystine bridges. correct incorrect

A heterotrimer held together by cysteine bridges. correct incorrect

A monomer. correct incorrect

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. Which of the following is true about insulin production?

Insulin is released from the cell as soon as it is produced. correct incorrect

Insulin is slowly but constitutively released from the cell. correct incorrect

Insulin release is regulated and involves vesicular storage and transport. correct incorrect

Insulin is only ever expressed when needed. correct incorrect

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. The insulin receptor has which of the following structures?

It is a tetramer with an α₂β₂ structure. correct incorrect

It is a monomer. correct incorrect

It is a dimer. correct incorrect

It is a homo-tetramer with an α₄ structure. correct incorrect

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. Insulin is perceived at which cellular location?

Plasma membrane. correct incorrect

Mitochondria. correct incorrect

Nucleus. correct incorrect

Endoplasmic reticulum correct incorrect

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. The insulin receptor is which of the following?

A receptor with seven α-helices (7TM receptor). correct incorrect

A G protein coupled receptor. correct incorrect

A nuclear steroid receptor. correct incorrect

A receptor tyrosine kinase (RTK). correct incorrect

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. Lack of insulin production causes which of the following?

Type 1 diabetes. correct incorrect

Type 2 diabetes. correct incorrect

Cholera. correct incorrect

Whooping cough. correct incorrect

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. Which of the following is not true?

Perception of insulin can alter rates of gene expression. correct incorrect

Perception of insulin can alter rates of metabolism. correct incorrect

Perception of insulin can cause the production of PtdInsP₃ in membranes. correct incorrect

Perception of insulin can only cause one effect in cells correct incorrect

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. Glucagon is which of the following?

A steroid hormone. correct incorrect

A peptide hormone comprising of 29 amino acids. correct incorrect

A peptide hormone comprising of two subunits. correct incorrect

A gas. correct incorrect

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. Glucagon is perceived in cells by the use of which of the following?

A nuclear receptor. correct incorrect

A RTK. correct incorrect

A steroid receptor. correct incorrect

A GPCR. correct incorrect