Chapter 15 Multiple choice questions

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How heritable is mouse behavior? Select correct answer.

Not much at all correct incorrect

About the same as in humans correct incorrect

Varies so much from trait to trait that it's meaningless to give an average value correct incorrect

Highly heritable correct incorrect

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What methods demonstrate that a trait is heritable in mice? Select all correct answers.

Comparisons of the trait in inbred strains correct incorrect

Artificial selection applied to the trait in a cross between two inbred strains correct incorrect

Examining the second generation of a cross between two strains correct incorrect

Twin studies correct incorrect

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What do selection experiments tell us about the heritability of rodent behavior? Select all correct answers.

They provide accurate estimates of heritability correct incorrect

They can distinguish polygenic architectures from Mendelian correct incorrect

They can provide accurate estimates of the number of loci that contribute to a trait correct incorrect

They can distinguish dominant from recessive genetic action on a trait correct incorrect

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Can selection experiments make rodent models of psychiatric disease? Select correct answer.

No, because there are no reliable ways to tell if a mouse or rat has an abnormal behavior correct incorrect

Selection can change behavior and can produce strains with heritable differences in behavior correct incorrect

Animal models produced through selection might reflect some aspects of the human illness correct incorrect

Rodent models from selection experiments can show heritable differences but the results of the selection experiment are hard to interpret because of the effects of linkage disequilibrium on correlated traits correct incorrect

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What is the difference between a chromosome substitution strain (CSS) and a recombinant inbred strain (RI)? Select correct answer.

CSS have one whole chromosome derived from one strain and all other chromosomes from a second strain, while the chromosomes of RIs are a mosaic of two strains correct incorrect

RIs are derived from two strains while CSS are descended from more than two strains correct incorrect

CSS have substituted half their chromosomes with those of another strain, while RIs are heterozygous at all loci correct incorrect

CSS and RI are both examples of mosaic populations, the difference only being in the choice of parental strains from which they derive correct incorrect

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How can inbred strains be used to map a genetic effect on behavior to part of a chromosome? Select all correct answers.

By comparing the behavior of chromosome substitution strains correct incorrect

By comparing the behavior of a panel of recombinant inbred strains correct incorrect

By setting up a cross between two inbred strains and testing the offspring (the F1 generation) correct incorrect

By setting up a cross between two inbred strains and testing the second generation offspring (the F2 generation) correct incorrect

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What strategies are available to map genetic loci at high resolution? Select all correct answers.

Heterogeneous stocks correct incorrect

A collection of recombinant inbreds and classical inbreds (the hybrid mouse diversity panel) correct incorrect

Commercially available outbred mice correct incorrect

Collaborative cross mice correct incorrect

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What's the best way to identify the genes that contribute to behavioral variation in mice? Select all correct answers.

There is no agreed strategy correct incorrect

Outbred mice provide high resolution mapping but require large numbers of animals and a complex analysis correct incorrect

Collaborative Cross inbred mice provide a quick and inexpensive way to find genes underlying behavior correct incorrect

Wild caught mice can be used to find genes involved in behavior correct incorrect

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What has genetic mapping told us about the genetic architecture of behavior in rodents? Select all correct answers.

It is completely different from the genetic architecture of behavior in humans correct incorrect

It is due to a large number of loci each making a relatively small contribution to the phenotype correct incorrect

Genetic interactions with the environment are large and pervasive correct incorrect

Large effect coding variants are common correct incorrect

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How does the genetic architecture of behavior differ between rodents and humans? Select correct answer.

It is identical correct incorrect

It depends on the mapping population correct incorrect

The genetic architecture of behavior in mice consists of a small number of loci explaining most of the behavioral variation, while in humans it is much more polygenic correct incorrect

There is a much larger contribution of gene by environment interactions in mouse populations correct incorrect

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Can studying naturally occurring genetic variants in mice be used to identify genes involved in behavior? Select all correct answers.

Using high resolution mapping populations and gene knockout interaction tests, genes for behavior can be identified correct incorrect

Sequencing the genomes of inbred mouse strains can be used to identify genes correct incorrect

The application of CRISPR in mouse genetics has been used to find genes for behavior correct incorrect

Combined expression and mapping data can be used to suggest candidate genes underlying behavior correct incorrect

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Do the position and the molecular nature of a genetic variant alter the likelihood that it influences behavior? Select all correct answers.

No, the position and molecular nature of variants is irrelevant to their effect on behavior correct incorrect

Coding variants have larger effects than non-coding variants correct incorrect

Intergenic variants are common, but have the smallest effects correct incorrect

There are no instances where the effect of a variant can be explained by its location in the genome correct incorrect