Chapter 1 Multiple choice questions

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. Which is the best description of cancer?

Cancer is a single disease that is always fatal. correct incorrect

Cancer is a genomic disease. correct incorrect

Cancer is a disease of abnormal cells. correct incorrect

Cancer is a set of diseases characterized by deregulated cell growth and survival. correct incorrect

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. Which of the following are examples of oncogenes?

RB-1 correct incorrect

C-MYC correct incorrect

RAS correct incorrect

BCR-ABL correct incorrect

PTEN correct incorrect

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. Which of the following are involved in DNA repair?

Non-homologous end joining correct incorrect

Base excision repair correct incorrect

Telomere maintenance correct incorrect

Microsatellite instability correct incorrect

Xeroderma pigmentosum correct incorrect

BRCA1 and BRCA2 correct incorrect

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. Which of the following viruses are implicated in causing cancer?

Human papilloma virus (HPV) correct incorrect

Oncolytic virus (ONYX-015) correct incorrect

Hepatitis B virus (HBV) correct incorrect

Epstein-Barr virus (EBV) correct incorrect

Human immunodeficiency virus (HIV) correct incorrect

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. Which of the following statements on carcinogenesis are true?

Genes can drive cancer when mutated, amplified, or deleted. correct incorrect

Gene expression that has been deregulated by epigenetic changes can drive cancer progression. correct incorrect

The number of genes that are changed in a cancer is highly variable. correct incorrect

TP53 is always mutated in cancer. correct incorrect

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. Which of the following statements relating to large-scale cancer genomic studies are true?

They study the totality of DNA sequence and/or gene expression differences between tumour cells and normal cells. correct incorrect

They use high throughput technologies like exome or whole genome sequencing. correct incorrect

They build our understanding of the genetic basis of tumour cell proliferation and cancer genome evolution. correct incorrect

They help identify passenger mutations that can be used as drug targets. correct incorrect

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. Which of the following statements are true?

Tumourigenesis involves multiple genetic and epigenetic changes. correct incorrect

Proto-oncogenes cause cancer. correct incorrect

Changes occur over time providing an explanation for higher occurrence of cancer in older people. correct incorrect

Colorectal cancer often starts with the development of a benign adenoma. correct incorrect

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. Which of the following are mechanisms by which oncogenic viruses cause cancers?

E6 and E7 oncoproteins expressed by HPVs inactivate p53 and pRB functions respectively. correct incorrect

Downregulation of telomerase through integration of HBV genome near the hTERT gene of the host genome correct incorrect

Inactivation of the NER DNA repair pathway through production of the oncoprotein HBX by the Hepatitis B virus correct incorrect

Chronic inflammation resulting from persistent infection with some oncogenic viruses leading to activation of pro-carcinogenic pathways correct incorrect