Chapter 1 Multiple choice questions

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. How many different cell types does an adult mammal have?

A few tens correct incorrect

A few hundred correct incorrect

A few thousand correct incorrect

Tens of thousands correct incorrect

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. Which of the following best defines a stem cell?

A cell from the early embryo correct incorrect

A cell that is still able to multiply correct incorrect

A cell whose multiplication can give rise to more than one daughter cell type correct incorrect

A cell whose multiplication can give rise to any daughter cell type correct incorrect

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. Which of the following properties makes mammalian cells more useful than bacteria for making mammalian proteins?

They grow faster. correct incorrect

They are easier and cheaper to culture. correct incorrect

Only mammalian cells can handle transcript splicing. correct incorrect

Only mammalian cells can add the correct sugar side-chains to mammalian proteins. correct incorrect

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. Which of the following best defines the term 'selection' when used in a description of transfecting a synthetic biological construct into mammalian cells?

Choosing which construct to make or buy correct incorrect

Choosing what cell type to use correct incorrect

Choosing what transfection method to use correct incorrect

Treating cells with an agent lethal to any that have not integrated the construct into their genome correct incorrect

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. A researcher engineers a synthetic biological construct into wild-type mouse embryonic stem (ES) cells and injects these cells into a host early mouse embryo. Which is the earliest generation in which she might expect to find mice in which all somatic cells will carry the synthetic biological construct?

The generation made directly by the host embryo (F0). correct incorrect

The children of the mice made directly by the host embryo (F1). correct incorrect

The grand-children of the mice made directly by the host embryo (F2). correct incorrect

No generation will include such mice. correct incorrect

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. Which of the following is most likely to be a problem in the human body accepting synthetic biological devices that include non-human proteins?

The nervous system correct incorrect

The innate immune system correct incorrect

The adaptive immune system correct incorrect

The protein synthesis system correct incorrect

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. What name is given to the separation of functions into different spaces?

Compartmentalization correct incorrect

Segregation correct incorrect

Separation correct incorrect

Localization correct incorrect

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. Which of the following options has its structure specified most directly by genes?

Amino acids correct incorrect

Peptide chains of proteins correct incorrect

Tissue anatomy correct incorrect

Body anatomy correct incorrect

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. Which of the following synthetic biology projects would be most likely to successfully treat type I diabetes mellitus?

Engineering into the body a new enzyme to destroy insulin in response to blood glucose correct incorrect

Engineering into the body a system to release insulin in response to blood glucose correct incorrect

Engineering into the body a system to reduce secretion of appetite-driving hormones correct incorrect

Engineering into the body a system to inhibit fat cell proliferation correct incorrect

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. In the context of pharmacology, what is a biologic?

A drug made by, or from, a living organism correct incorrect

A drug that interacts with a biological pathway correct incorrect

A large pharmacologically-active molecule, usually a protein correct incorrect

A pharmacologically active compound made by synthetic biological techniques correct incorrect