• Benkovic, S.J.A., and Hammes-Schiffer, S. (2003). A perspective on enzyme catalysis. Science, 301, 1196–202.

Starts with an overview of models that explain enzyme catalysis, and continues with a case study of a single enzyme—dihydrofolate reductase.

• Goodey, N.M., and Benkovic, S.J. (2008). Allosteric regulation and catalysis emerge via a common route. Nature Chemical Biology, 4, 474–82.

Starts with a useful review of the evolution of the concept of allostery before moving into more

advanced territory.

• Dodson, G., and Wlodawer, A. (1998). Catalytic triads and their relatives. Trends Biochem. Sci., 23, 347–52.

A review of the mechanism of chymotrypsin catalysis, together with a discussion of other enzymes using the ‘serine’ catalytic triad and their evolutionary relationships.