Chapter 19 Further reading

Nitrogen metabolism: nucleotide metabolism

• Huennekens, F.M. (1994). The methotrexate story: a paradigm for development of cancer therapeutic agents. Adv. Enzyme Regul., 34, 392–419.

Gives a history of the antifolate drug, the structure of dihydrofolate reductase, and development of methotrexate resistance in cells.

• Icard, P. and Lincet, H. (2012). A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells. Biochimica et Biophysica Acta-Reviews on Cancer,

1826(2), 423–33. 

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