Chapter 19 Further reading
Nitrogen metabolism: nucleotide metabolism
• Huennekens, F.M. (1994). The methotrexate story: a paradigm for development of cancer therapeutic agents. Adv. Enzyme Regul., 34, 392–419.
Gives a history of the antifolate drug, the structure of dihydrofolate reductase, and development of methotrexate resistance in cells.
• Icard, P. and Lincet, H. (2012). A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells. Biochimica et Biophysica Acta-Reviews on Cancer,
1826(2), 423–33.