Chapter 3 Multiple Choice Questions

. Which of the following techniques may be used to probe the kinetics of inclusion complex formation between β-cyclodextrin and cholesterol?

. Which of the following molecules is least likely to form inclusion complexes with cyclodextrins?
(1) ferrocene; (2) carborane; (3) (Z)-azobenzene

. A molecular container has a cavity with a total volume of 1000 Å3. Three potential guest molecules X, Y, and Z have molecular volumes of 248, 534, and 829 Å3 respectively. Arrange these three guest molecules in order of their expected binding affinities with the molecular container, starting with the strongest binding.

. A host molecule for cyclic urea X below has the following general structure:

An illustration shows two chemical structures. The first chemical structure X shows a five-membered C 3 N 2 ring. The C atom between the two N atoms is double bonded with an O atom. Both the N atoms are fused with an H atom, in turn. The second host chemical structure shows, from left to right following rings are bonded with two common atoms between every two rings: an R-group represented by a circle, a six-membered C 6 benzene ring, a five-membered C 4 N piperidine ring where N is fused with an H atom, a six-membered C 6 cyclohexane ring, a six-membered C 5 N ring, a six-membered cyclohexane ring, a five-membered C 4 N piperidine ring where N is fused with an H atom, a six-membered C 6 benzene ring, and an R-group represented by a circle.

Which of the following possibilities for the heterocycle R is likely to give the strongest host-guest binding in chloroform?

. Which of the following compounds will be least likely to form complexes with compound Y below?

An illustration of a chemical structure shows O H single-bond C H 2 single bond C H 2 single bond O single bond C H 2 single bond C H 2 single-bonded with the N atom of a C 4 N ring, where the neighboring C atoms of N are double-bonded with O atoms, in turn, C 4 N ring is attached with a benzene ring having two common C atoms, then it attached with a C 4 N ring, where the neighboring C atoms of N are double-bonded with O atoms, in turn, N of the C 4 N ring single-bonded with C H 2, single bond C H 2 single bond O single bond C H 2 single bond C H 2 single bond O H.

. Which of the following guest molecules will be expected to bind most strongly with receptor M below?

An illustration of a chemical structure shows, from left to right followings molecules are bonded with two common atoms between every two molecules: N H 2 single bond, C 5 N ring, C 6 cyclohexane ring, C 5 N ring, C 6 cyclohexane ring, C 5 N ring, C 5 N ring, C 6 cyclohexane ring, C 5 N ring, C 6 cyclohexane ring, C 5 N ring single-bonded with N H 2.

. Which of the following are possible applications of host-guest inclusion complexes?
(1) catalysis
(2) molecular recognition
(3) stabilization of reactive molecules

. Which of the following supramolecular interactions contribute towards formation of inclusion complexes with CB[7]?
(1) Hydrogen bonding
(2) Hydrophobic interactions
(3) Ion-dipole interactions

. In designing a molecular receptor for the nucleobase, guanine, to function in polar aprotic solvents, which of the following molecular design features would likely be the most important for engineering selectivity?

An illustration of a chemical structure Guanine shows a five-membered C 3 N 2 ring, where bottom N is fused with an H atom. This ring is attached with a C 4 N 2 ring, where the top C atom or the left of the N atom is double-bonded with an O atom. This N atom is fused with an H atom and there is an N atom opposite to C O. The C atom between the N atoms is single-bonded with N H 2.

. A receptor for a monosaccharide has the following general structure:

An illustration of a chemical structure Guanine shows two symmetric molecules facing each other. The molecule is a six-membered C 6 ring single-bonded with two C O N H at the top right and bottom right alternating position, where an R group is single-bonded at the left C atom. Two molecules are shown at the top middle and bottom middle. This new molecule consists of three six-membered C 6 rings attached having two common C atoms between every two rings. The opposite C atoms of the middle C 6 rings in both the new molecules are bonded with the respective left and right N atoms of the C O N H 2 molecules.

Which of the following monosaccharides is likely to be the most strongly bound to this receptor in water?

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