FIGURE 6.23 The number of germ cells in the human ovary changes over the life span. (After T. G. Baker. 1971. Am J Obstet Gynecol 110: 746–761, based on T. G. Baker and S. Zuckerman. 1963. Proc
R Soc Lond 158: 417–433; and E. Block. 1952. Acta Anat 14: 108–123.)After H. K. Salz. 2011. Curr Opin Genet Dev 21: 395–400.)

B. A. Krizek and J. C. Fletcher. 2005. Nat Rev Genet 6: 688–698

Burns. 1955. Proc Natl Acad Sci USA 41: 669–676

M. Dym and D. W. Fawcett. 1971. Biol Reprod 4: 195–215

Abe, M. and 9 others. 2005. FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex. Science 309: 1052–1056.
PubMed Link

Abrol, D. P. 2012. Historical perspective. In D. P. Abrol (ed.), Pollination Biology. Springer, Dordrecht.

Ainsworth, C. 2015. Sex redefined. Nature 518: 288–291.
PubMed Link

Anderson, E. L., A. E. Baltus, H. L. Ropers-Gajadien, T. J. Hassold, D. G. de Rooij, A. M. van Pelt and D. C. Page. 2008. Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Proc. Natl. Acad. Sci. USA 105: 14976–14980.
PubMed Link

Anderson, R., T. K. Copeland, H. Schöler, J. Heasman and C. Wylie. 2000. The onset of germ cell migration in the mouse embryo. Mech. Dev. 91: 61–68.
PubMed Link

Andersson, S., D. M. Berman, E. P. Jenkins and D. W. Russell. 1991. Deletion of steroid 5a-reductase 2 gene in male pseudohermaphroditism. Nature 354: 159–161.
PubMed Link

Arango, N. A., R. Lovell-Badge and R. R. Behringer. 1999. Targeted mutagenesis of the endogenous mouse Mis gene promoter: In vivo definition of genetic pathways of vertebrate sexual development. Cell 99: 409–419.
PubMed Link

Argunhan, B., and 9 others. 2017. Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis. EMBO J. 36: 2488–2509.
PubMed Link

Austin, J., A. Tamar-Mattis, T. Mazur, M. J. Henwood and W. C. Rossi. 2011. Disorders of sex development: When and how to tell the patient. Pediatr. Endocrinol. Rev. 83: 213–217.
PubMed Link

Baker, B. S. 1989. Sex in flies: The splice of life. Nature 340: 521–524.
PubMed Link

Baker, B. S., B. J. Taylor and J. C. Hall. 2001. Are complex behaviors specified by directed regulatory genes? Reasoning from Drosophila. Cell 105: 13–24.
PubMed Link

Baker, B. S., R. N. Nagoshi and K. C. Burtis. 1987. Molecular genetic aspects of sex determination in Drosophila. BioEssays 6: 66–70.
PubMed Link

Baker, T. G. 1970. Primordial germ cells. In C. R. Austin and R. V. Short (eds.), Reproduction in Mammals, Vol. 1: Germ Cells and Fertilization. Cambridge University Press, Cambridge, 1–13.

Baltus, A. E., D. B. Menke, Y. C. Hu, M. L. Goodheart, A. E. Carpenter, D. G. de Rooij and D. C. Page. 2006. In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat. Genet. 38: 1430–1434.
PubMed Link

Barrionuevo, F., S. Bagheri-Fam, J. Klattig, R. Kist, M. M. Taketo, C. Englert and G. Scherer. 2006. Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol. Reprod. 74: 195–201.
PubMed Link

Bell, L. R., J. I. Horabin, P. Schedl and T. W. Cline. 1991. Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila. Cell 65: 229–239.
PubMed Link

Berkovitz, G. D., P. Y. Fechner, S. M. Marcantonio, G. Bland, G. Stetten, P. N. Goodfellow, K. D. Smith and C. J. Migeon. 1992. The role of the sex-determining region of the Y chromosome (SRY) in the etiology of 46,XX true hermaphrodites. Hum. Genet. 88: 411–416.
PubMed Link

Beukeboom, L. W. 1995. Sex determination in Hymenoptera: A need for genetic and molecular studies. BioEssays 17: 813–817.
PubMed Link

Bieser, K. L. and T. Wibbels. 2014. Chronology, magnitude, and duration of expression of putative sex-determining/differentiation genes in a turtle with temperature-dependent sex determination. Sexual Dev. 8: 364–375.
PubMed Link

Birk, O. S. and 11 others. 2000. The LIM homeobox gene LHX9 is essential for mouse gonad formation. Nature 403: 909–913.
PubMed Link

Boggs, R. T., P. Gregor, S. Idriss, J. M. Belote and M. McKeown. 1987. Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene. Cell 50: 739–747.
PubMed Link

Bowles, J. and 11 others. 2006. Retinoid signaling determines germ cell fate in mice. Science 312: 596–600.
PubMed Link

Bradford, S. T. and 10 others. 2009a. The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol. Reprod. 80: 1178–1188.
PubMed Link

Bradford, S. T., D. Wilhelm, R. Bandiera, V. Vidal, A. Schedl and P. Koopman. 2009b. A cell-autonomous role for WT1 in regulating Sry in vivo. Hum. Mol. Genet. 18: 3429–3438.
PubMed Link

Brar, G. A., A. Hochwagen, L. S. Ee and A. Amon. 2009. The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing. Mol. Biol. Cell 20: 1030–1047.
PubMed Link

Braun, R. E., R. R. Behringer, J. J. Peschon, R. L. Brinster and R. D. Palmiter. 1989. Genetically haploid spermatids are phenotypically diploid. Nature 337: 373–376.
PubMed Link

Brennan, J. and B. Capel. 2004. One tissue, two fates: Molecular genetics that underlie testis versus ovary development. Nat. Rev. Genet. 5: 509–521.
PubMed Link

Bull, J. J. 1980. Sex determination in reptiles. Q. Rev. Biol. 55: 3–21.

Bullejos, M. and P. Koopman. 2005. Delayed Sry and Sox9 expression in developing mouse gonads underlie B6-YDOM sex reversal. Dev. Biol. 278: 473–481.
PubMed Link

Burger, H. G. 2002. Androgen production in women. Fert. Steril. 77: 3–5.
PubMed Link

Burke, B. 2018. LINC complexes as regulators of meiosis. Curr. Opin. Cell Biol. 52: 22–29
PubMed Link.

Cakmak, H., F. Franciosi, A. M. Zamah, M. I. Cedars and M. Conti. 2016. Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc. Natl. Acad. Sci. USA 113: 2424–2429.
PubMed Link

Carpenter, M. 2016. The human rights of intersex people: Addressing harmful practices and rhetoric of change. Reprod. Health Matters 47: 74–84.
PubMed Link

Carré, G. A., P. Siggers, M. Xipolita, P. Brindle, B. Lutz, S. Wells, and A. Greenfield. 2018. Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal. Hum. Mol. Genet. 27: 190–198.

Chassot, A. A., E. P. Gregoire, R. Lavery, M. M. Taketo, D. G. de Rooij, I. R. Adams and M. C. Chaboissier. 2011. RSPO1/b-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLOS ONE 6: e25641.
PubMed Link

Chen, C.-K. and 9 others. 2016 Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science 354: 468– 472.
PubMed Link

Chen, J. and 11 others. 2013. Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat. Cell Biol. 15: 1415–1423.
PubMed Link

Chen, L. Y., W. D. Willis and E. M. Eddy. 2016a. Targeting the Gdnf gene in peritubular myoid cells disrupts undifferentiated spermatogonial cell development. Proc. Natl. Acad. Sci. USA 113: 1829–1834.
PubMed Link

Chen, Q. and 13 others. 2016b. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351: 397–400.
PubMed Link

Cheng, S. and 13 others. 2022. Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science 378(6617):eabq4835.
PubMed Link

Clarke, B. L. and S. Khosla. 2009. Androgens and bone. Steroids 74: 296–305.
PubMed Link

Coen, E. S. and E. M. Meyerowitz. 1991. The war of the whorls: Genetic interactions controlling flower development. Nature 353: 31–37.
PubMed Link

Comings, D. E. 1968. The rationale for an ordered arrangement of chromatin in the interphase nucleus. Am. J. Hum. Genet. 20: 440–460.
PubMed Link

Cool, J. and B. Capel. 2009. Mixed signals: Development of the testis. Semin. Reprod. Med. 27: 5–13.
PubMed Link

Couse, J. F. and K. S. Korach. 2001. Contrasting phenotypes in reproductive tissues of female estrogen receptor null mice. Ann. N.Y. Acad. Sci. 948: 1–8.
PubMed Link

Couse, J. F., S. C. Hewitt, D. O. Bunch, M. Sar, V. R. Walker, B. J. Davis and K. S. Korach. 1999. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 286: 2328–2331.
PubMed Link

Crain, D. A. and L. J. Guillette, Jr. 1998. Reptiles as models of contaminant-induced endocrine disruption. Anim. Reprod. Sci. 53: 77–86.
PubMed Link

Crews, D. 2003. Sex determination: Where environment and genetics meet. Evol. Dev. 5: 50–55.
PubMed Link

Cunha, G. R. and 17 others. 2014. Development of the external genitalia: Perspectives from the spotted hyena (Crocuta crocuta). Differentiation 87: 4–22.
PubMed Link

Cunha, G. R. and L. Baskin. 2018. Development of human male and female urogenital tracts. Differentiation 103: S0301–S4681.
PubMed Link

de Rooij, D. G. 2017. The nature and dynamics of spermatogonial stem cells. Development 144: 3022–3030.
PubMed Link

de Rooij, D. G. and L. D. Russell. 2000. All you wanted to know about spermatogonia but were afraid to ask. J. Androl. 21: 776–798.
PubMed Link

de Santa Barbara, P., B. Moniot, F. Poulat and P. Berta. 2000. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev. Dyn. 217: 293–298.
PubMed Link

Donoughe, S., T. Nakamura, B. Ewen-Campen, D. A. Green II, L. Henderson and C. G. Extavour. 2014. BMP signaling is required for the generation of primordial germ cells in an insect. Proc. Natl. Acad. Sci. USA 111: 4133–4138.
PubMed Link

Dossin, F. and 14 others. 2020. SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature 578: 455–460.
PubMed Link

Dreger, A. D., C. Chase, A. Sousa, P. A. Gruppuso and J. Frader. 2005. Changing the nomenclature/taxonomy for intersex: A scientific and clinical rationale. JPEM 18: 729–733.
PubMed Link

Dudley, B. M., C. Runyan, Y. Takeuchi, K. Schaible and K. Molyneaux. 2007. BMP signaling regulates PGC numbers and motility in organ culture. Mech. Dev. 124: 68–77.
PubMed Link

Dudley, B., C. Palumbo, J. Nalepka and K. Molyneaux. 2010. BMP signaling controls formation of a primordial germ cell niche within the early genital ridges. Dev. Biol. 343: 84–93.
PubMed Link

Dulac, C. and Kimchi, T. 2008. Neural mechanisms underlying sex-specific behaviors in vertebrates Curr. Opin. Neurobiol. 17:675–683.
PubMed Link

Dunce, J. M., O. M. Dunne, M. Ratcliff, C. Millán, S. Madgwick, I. Usón and O. R. Davies. 2018. Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly. Nat. Struct. Mol. Biol. 25: 557–569.
PubMed Link

Dym, M. 1977. The male reproductive system. In L. Weiss and R. O. Greep (eds.), Histology, 4th Ed. McGraw-Hill, New York, 979–1038.

Dym, M. 1994. Spermatogonial cells of the testis. Proc. Natl. Acad. Sci. USA 91: 11287–11289.
PubMed Link

Eliot, L., A. Ahmed, H. Khan and J. Patel, J. 2021. Dump the dimorphism: Comprehensive synthesis of human brain studies reveals few male-female differences beyond size. Neurosci. Biobehav. Rev. 125: 667–697.
PubMed Link

Ewen-Campen, B., E. E. Schwager and C. G. Extavour. 2010. The molecular machinery of germ line specification. Mol. Reprod. Dev. 77: 3–18.
PubMed Link

Fausto-Sterling, A. 1993. The five sexes: Why male and female are not enough. The Sciences 33: 20–24.

Fausto-Sterling, A. 2000. Sexing the Body: Gender Politics and the Construction of Sexuality. Basic Books, New York.

Fayomi, A. P. and K. E. Orwig. 2018. Spermatogonial stem cells and spermatogenesis in mice, monkeys and men. Stem Cell Res. 29: 207–214.
PubMed Link

Feng, R. and 33 others. 2016. Mutations in TUBB8 and human oocyte meiotic arrest. New Engl. J. Med. 374: 223–232.
PubMed Link

Ford, C. E., K. W. Jones and P. E. Polani. 1959. A sex chromosomal anomaly in a case of gonadal dysgenesis (Turner’s syndrome). Lancet 1: 771–713.
PubMed Link

Fujiwara, T., N. R. Dunn, and B. L. Hogan. 2001. Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. Proc. Natl. Acad. Sci. USA 98: 13739–13744.
PubMed Link

Ge, C. and 8 others. 2018. The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species. Science 360: 645–648.
PubMed Link

Ge, C., J. Ye, H. Zhang, Y. Zhang, W. Sun, Y. Sang, B. Capel and G. Qian. 2017. Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination. Development 144: 2222–2233.
PubMed Link

Gempe, T., M. Hasselmann, M. Schiøtt, G. Hause, M. Otte and M. Beye. 2009. Sex determination in honeybees: Two separate mechanisms induce and maintain the female pathway. PLOS Biol. 7: e1000222.
PubMed Link

Gilbert, S. F. 1978. The embryological origins of the gene theory. J. Hist. Biol. 11: 307–351.
PubMed Link

Gilbert, S. F. and C. Pinto-Correia. 2017. Fear, Wonder, and Science in the New Age of Reproductive Biotechnology. New York: Columbia University Press.

Gonen, N. and 9 others. 2018. Sex reversal following deletion of a single distal enhancer of Sox9. Science 360: 1469–1473.
PubMed Link

González, A. N., H. Lu and J. W. Erickson. 2008. A shared enhancer controls a temporal switch between promoters during Drosophila primary sex determination. Proc. Natl. Acad. Sci. USA 105: 18436–18441.
PubMed Link

Griswold, M. D., C. A. Hogarth, J. Bowles and P. Koopman. 2012. Initiating meiosis: The case for retinoic acid. Biol. Reprod. 86: 35.
PubMed Link

Gross, R. E. 2022. Vagina Obscura: An Anatomical Voyage. New York: W. W. Norton.

Gu, Y., C. Runyan, A. Shoemaker, A. Surani and C. Wylie. 2009. Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration. Development 136: 1295–1303.
PubMed Link

Haering, C. H., A. M. Farcas, P. Arumugam, J. Metson and K. Nasmyth. 2008. The cohesin ring concatenates sister DNA molecules. Nature 454: 297–301.
PubMed Link

Hamazaki, N. and 12 others 2021. Reconstitution of the oocyte transcriptional network with transcription factors. Nature 589: 264–269.
PubMed Link

Hammond, A. and 12 others. 2021. Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field. Nature Comm. 12(1): 4589.
PubMed Link

Hancock, G. V., S. E. Wamaitha, L. Peretz and A. T. Clark. 2021. Mammalian primordial germ cell specification. Development 148(6):dev189217.
PubMed Link

Handel, M. A. and J. J. Eppig. 1998. Sexual dimorphism in the regulation of mammalian meiosis. Curr. Topics Dev. Biol. 37: 333–358.
PubMed Link

Hara, K., T. Nakagawa, H. Enomoto, M. Suzuki, M. Yamamoto, B. D. Simons and S. Yoshida. 2014. Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states. Cell Stem Cell 4: 658–672.
PubMed Link

Harris, A. and 21 others. 2018. ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proc. Natl. Acad. Sci. USA 115: 5474–5479.
PubMed Link

Hayashi, Y., M. Hayashi, and S. Kobayashi. 2004. Nanos suppresses somatic cell fate in Drosophila germ line. Proc. Natl. Acad. Sci. USA 101: 10338–10342.
PubMed Link

Hess, R. A. 2000. Oestrogen in fluid transport in efferent ducts of the male reproductive tract. Rev. Reprod. 5: 84–92.
PubMed Link

Hess, R. A., D. Bunick, K.-H. Lee, J. Bahr, J. A. Taylor, K. S. Korach and D. B. Lubahn. 1997. A role for oestrogens in the male reproductive system. Nature 390: 509–512.
PubMed Link

Hill, P. W. S. and 16 others. 2018. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Nature 555: 392–396.
PubMed Link

Huang, B., S. Wang, Y. Ning, A. N. Lamb and J. Bartley. 1999. Autosomal XX sex reversal caused by duplication of SOX9. Am. J. Med. Genet. 87: 349–353.
PubMed Link

Huang, S., Ye, L., and Chen, H. 2017. Sex determination and maintenance: the role of DMRT1 and FOXL2. Asian. J. Andrology 19: 619–624.
PubMed Link

Hughes, I. A., C. Houk, S. F. Ahmed and P. A. Lee. 2006. Consensus statement on management of intersex disorders. J. Pediatr. Urol. 2: 148–162
PubMed Link

Hull, C. L. and A. Fausto-Sterling. 2003. Letter to the editor: How sexually dimorphic are we? Am. J. Hum. Biol. 15: 112–114.
PubMed Link

Ilgin, N. A, and Ilgin, V. N. 1930. Temperature effects on the color of the Siamese cat. J. Hered. 21: 309–318.

Imperato-McGinley, J., L. Guerrero, T. Gautier and R. E. Peterson. 1974. Steroid 5a-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science 186: 1213–1215.
PubMed Link

Isaacson, D. and 10 others. 2018. Three-dimensional imaging of the developing human fetal urogenital-genital tract: Indifferent stage to male and female differentiation. Differentiation 103: S0301–S4681.
PubMed Link

Jääskeläinen, J. 2012. Molecular biology of androgen insensitivity. Mol. Cell Endocrinol. 352: 4–12.
PubMed Link

Jacobs, P. A. and J. A. Strong. 1959. A case of human intersexuality having a possible XXY sex-determining mechanism. Nature 183: 302–303.
PubMed Link

Jameson, S. A., Y-T. Lin and B. Capel. 2012. Testis development requires the repression of Wnt4 by Fgf signaling. Dev. Bio. 370: 24–32.
PubMed Link

Jensen, M. P., C. D. Allen, T. Eguchi, I. P. Bell, E. L. LaCasella, W. A. Hilton, C. A. M. Hof and P. H. Dutton. 2018. Environmental warming and feminization of one of the largest sea turtle populations in the world. Curr. Biol. 28: 154–159.
PubMed Link

Johnson, M. L., A. A. Nagengast and H. K. Salz. 2010. PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila. PLOS Genet. 6: e1000872.
PubMed Link

Kanatsu-Shinohara, M., M. and 9 others. 2008. Homing of mouse spermatogonial stem cells to germline niche depends on b1-integrin. Cell Stem Cell 3: 533–542.
PubMed Link

Kashimada, K. and P. Koopman. 2010. Sry: The master switch in mammalian sex determination. Development 137: 3921–3930.
PubMed Link

Keyes, L. N., T. W. Cline and P. Schedl. 1992. The primary sex determination signal of Drosophila acts at the level of transcription. Cell 68: 933–943.
PubMed Link

Kim, K. S. and J. Kim. 2012. Disorders of sex development. Korean J. Urol. 53: 1-8.
PubMed Link

Kim, S., V. J. Bardell and D. Zarkower. 2007. Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation. Dev. Biol. 307: 314–325.
PubMed Link

Kobayashi, S., M. Yamada, M. Asaoka and T. Kitamura. 1996. Essential role of the posterior morphogen nanos for germline development in Drosophila. Nature 380: 708–711.
PubMed Link

Koopman, P., J. Gubbay, N. Vivian, P. Goodfellow and R. Lovell-Badge. 1991. Male development of chromosomally female mice transgenic for Sry. Nature 351: 117–121.
PubMed Link

Koubova, J., D. B. Menke, Q. Zhou, B. Capel, M. D. Griswold and D. C. Page. 2006. Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc. Natl. Acad. Sci. USA 103: 2474–2479.
PubMed Link

Krizek, B. A. 2015. Arabidopsis: Flower Development and Patterning. John Wiley & Sons, Ltd, Chichester.

Krizek, B. A. and J. C. Fletcher. 2005. Molecular mechanisms of flower development: An armchair guide. Nat. Rev. Genet. 6: 688–698.
PubMed Link

Kuroki, S. and M. Tachibana. 2018. Epigenetic regulation of mammalian sex determination. Mol. Cell Endocrinol. 468: 31–38.
PubMed Link

Kyrou, K. and 7 others. 2018. A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes. Nature Biotechnol. 36: 1062–1066.
PubMed Link

Lamothe, S., Bernard, V., and Christin-Maitre, S. 2020. Gonad differentiation toward ovary. Ann. Endocrinol. (Paris) 81: 83–88.
PubMed Link

Leclère, L., M. Jager, C. Barreau, P. Chang, H. Le Guyader, M. Manuel and E. Houliston. 2012. Maternally localized germ plasm mRNAs and germ cell/stem cell formation in the cnidarian Clytia. Dev. Biol. 364: 236–248.
PubMed Link

Levine, H., N. Jørgensen, A. Martino-Andrade, J. Mendiola, D. Weksler-Derri, I. Mindlis, R. Pinotti and S. H. Swan. 2017. Temporal trends in sperm count: A systematic review and meta-regression analysis. Hum. Reprod. Update 23: 646–659.
PubMed Link

Li, H.J., and W. C. Yang. 2020. Central cell in flowering plants: Specification, signaling, and evolution. Front. Plant Sci. 11:590307.
PubMed Link

Lian, H., L. Wang, L., N. Ma, C.-M. Zhou, L. Han, T.-Q. Zhang, and J.-W. Wang. 2021. Redundant and specific roles of individual MIR172 genes in plant development. PLoS Biol. 19:e3001044.
PubMed Link

Lillie, F. R. 1917. The freemartin: A study of the actions of sex hormones in foetal life of cattle. J. Exp. Zool. 23: 371–452.

Lochab, A. K. and C. G. Extavour. 2017. Bone morphogenetic protein (BMP) signaling in animal reproductive system development and function. Dev. Biol. 427: 258–269.
PubMed Link

Lomniczi, A., J. M. Castellano, O. K. Ronnekleiv, M. Bosch, G. Kaidar, J. G. Knoll, H. Wright, G. P. Pfeifer and S. R. Ojeda. 2013. Epigenetic control of female puberty. Nat. Neurosci. 16: 281–289.
PubMed Link

Londoño-Vásquez, D., K. Rodriguez-Lukey, S. K. Behura and A. Z. Balboula. 2022. Microtubule organizing centers regulate spindle positioning in mouse oocytes. Dev. Cell. 57: 197–211.
PubMed Link

Longo, F. J. 1997. Fertilization. Chapman and Hall, New York.

Lyons, L. A., D. L. Imes, H. C. Rah and R. A. Grahn. 2005. Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus). Anim Genet. 36(2):119–26.
PubMed Link

Maatouk, D. M., L. DiNapoli, A. Alvers, K. L. Parker, M. M. Taketo and B. Capel. 2008. Stabilization of b-catenin in XY gonads causes male-to-female sex-reversal. Hum. Mol. Genet. 17: 2949–2955.
PubMed Link

Margarit, E., M. D. Coll, R. Olivo, D. Gómez, A. Soler and F. Ballesta. 2000. SRY gene transferred to the long arm of the X chromosome in a Y-positive XX true hermaphrodite. Am. J. Med. Genet. 90: 25–28.
PubMed Link

Mark, M. and 8 others. 2008. STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation. J. Cell Sci. 121: 3233–3242.
PubMed Link

Marx, J. 1995. Mammalian sex determination: Snaring the genes that divide sexes for mammals. Science 269: 1824–1825.
PubMed Link

Mathews, K. W., M. Cavegn and M. Zwicky. 2017. Sexual dimorphism of body size is controlled by dosage of the X-chromosomal gene Myc and by the sex-determining gene tra in Drosophila. Genetics 205: 1215–1228.
PubMed Link

Matson, C. K. and D. Zarkower. 2012. Sex and the singular DM domain: Insights into sexual regulation, evolution and plasticity. Nat. Rev. Genet. 13: 163–174.
PubMed Link

Matson, C. K., M. W. Murphy, A. L. Sarver, M. D. Griswold, V. J. Bardwell, and D. Zarkower. 2011. DMRT1 prevents female reprogramming in the postnatal mammalian testis. Nature 476: 101–104.
PubMed Link

Matson, C. K., M. W. Murphy, M. D. Griswold, S. Yoshida, V. J. Bardwell and D. Zarkower. 2010. The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. Dev. Cell. 19: 612–624.
PubMed Link

McClelland, K., J. Bowles and P. Koopman. 2012. Male sex determination: Insights into molecular mechanisms. Asian J. Androl. 14: 164–171.
PubMed Link

McLaren, A. 1991. Development of the mammalian gonad: The fate of the supporting cell lineage. BioEssays 13: 151–156.
PubMed Link

McLaren, A. 1995. Germ cells and germ cell sex. Phil. Trans. Roy. Soc. London 350B: 229–233.
PubMed Link

Merke, D. P., S. R. Bornstein, N. A. Avila and G. P. Chrousos. 2002. Future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Ann. Intern. Med. 136: 320–334.
PubMed Link

Meyer, W. J., B. R. Migeon and C. J. Migeon. 1975. Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity. Proc. Natl. Acad. Sci. USA 72: 1469–1472.
PubMed Link

Meyerowitz, E. M., D. R. Smyth, and J. L. Bowman. 1989. Abnormal flowers and pattern formation in floral development. Development 106: 209–217.

Migeon, B. R. 2013. Females Are Mosaics: X-Inactivation and Sex Differences in Disease. Oxford University Press, New York.

Migeon, B. R. 2017. Choosing the active X: The human version of X inactivation. Trends Genet. 33: 899–909.
PubMed Link

Migeon, C. J. and A. B. Wisniewski. 2000. Human sex differentiation: From transcription factors to gender. Horm. Res. 53: 111–119.
PubMed Link

Mihajlović, A. I., and G. FitzHarris. 2018. Meiosis: SUMO keeps a tight grip on sister chromatids. Curr. Biol. 28: R671–R674.
PubMed Link

Mikedis, M. M. and 7 others. 2020. DAZL mediates a broad translational program regulating
PubMed Link

Miyawaki, S., S. Kuroki, R. Meda, N. Okashita, P. Koopman and M. Tachibana. 2020. The mouse Sry locus harbors a cryptic exon that is essential for male sex determination. Science 370: 121–124
PubMed Link

Mizoguchi, T. and 10 others. 2005. Distinct roles of GIGANTEA in promoting flowering and regulating circadian rhythms in Arabidopsis. Plant Cell. 17: 2255–2270.
PubMed Link

Molyneaux, K. A., J. Stallock, K. Schaible and C. Wylie. 2001. Time-lapse analysis of living mouse germ cell migration. Dev. Biol. 240: 488–498.
PubMed Link

Morgan, T. H. and C. B. Bridges. 1919. The origin of gynandromorphs. In Contributions to the Study of Drosophila. Publication 278. Carnegie Institution of Washington, Washington, DC, 1–122.

Moschall, R., M. Gaik, and J. Medenbach. 2017. Promiscuity in post-transcriptional control of gene expression: Drosophila sex-lethal and its regulatory partnerships. FEBS Lett. 591: 1471–1488.
PubMed Link

Mulvey, B. B., U. Olcese, J. R. Cabrera and J. I. Horabin. 2014. An interactive network of long non-coding RNAs facilitates the Drosophila sex determination decision. Biochim. Biophys. Acta 1839: 773–784.
PubMed Link

Nagahama, Y., T. Chakraborty, B. Paul-Prasanth, K. Ohta and M. Nakamura. 2020. Sex determination, gonadal sex differentiation, and plasticity in vertebrate species. Physiol Rev. 101: 1237–1308.
PubMed Link

Nagoshi, R. N., M. McKeown, K. C. Burtis, J. M. Belote and B. S. Baker. 1988. The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell 53: 229–236.
PubMed Link

Naillat, F., R. Prunskaite-Hyyryläinen, I. Pietilä, R. Sormunen, T. Jokela, J. Shan and S. J. Vainio. 2010. Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum. Mol. Genet. 19: 1539–1550.
PubMed Link

Nakagawa, T., M. Sharma, Y. Nabeshima, R. E. Braun and S. Yoshida. 2010. Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science 328: 62–67.
PubMed Link

Nakagawa. T. and 8 others. 2017. Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells. Development 144: 4137–4147.
PubMed Link

Newton, S. C., O. W. Blaschuk and C. F. Millette. 1993. N-cadherin mediates Sertoli cell-spermatogenic cell adhesion. Dev. Dyn. 197: 1–13.
PubMed Link

Nicholls, P. K. and 10 others. 2019. Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proc. Natl. Acad. Sci. USA. 116: 25677–25687.
PubMed Link

Nicholls, P. K. and D. C. Page. 2021. Germ cell determination and the developmental origin of germ cell tumors. Development 148(8):dev198150.
PubMed Link

Notaguchi, M. and 9 others. 2008. Long-distance, graft-transmissible action of Arabidopsis flowering locus T protein to promote flowering. Plant Cell Physiol. 49: 1645–1658.
PubMed Link

Ó’Maoiléidigh, D. S. and 11 others. 2021. Systematic analyses of the MIR172 family members of Arabidopsis define their distinct roles in regulation of APETALA2 during floral transition. PLoS Biol. 19(2):e3001043.
PubMed Link

Olmedo-Monfil, V. and 8 others. 2010. Control of female gamete formation by a small RNA pathway in Arabidopsis. Nature 464: 628–32.
PubMed Link

Ottolenghi, C. and 8 others. 2007. Loss of Wnt4 and Foxl2 leads to female-to-male sex 3804 reversal extending to germ cells. Hum. Mol. Genet. 16: 2795–2804.
PubMed Link

Ottolenghi, C., S. Omari, J. E. Garcia-Ortiz, M. Uda, L. Crisponi, A. Forabosco, G. Pilia and D. Schlessinger. 2005. Foxl2 is required for commitment to ovary differentiation. Hum. Mol. Genet. 14: 2053–2062.
PubMed Link

Palmer, S. J. and S. Burgoyne. 1991. XY follicle cells in the ovaries of XO/XY and XO/XY/XY mosaic mice. Development 111: 1017–1019.
PubMed Link

Pan, H., M. J. O’Brien, K. Wigglesworth, J. J. Eppig and R. M. Schultz. 2005.Transcript profiling during mouse oocyte development and the effect of gonadotropin priming and development in vitro. Dev. Biol. 286: 493–506.
PubMed Link

Parma, P., O. Radi, V. Vidal, M. C. Chaboissier, E. Dellambra, S. Valentini, L. Guerra, A. Schedl and G. Camerino. 2006. R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat. Genet. 38: 1304–1309.
PubMed Link

Pask, A. and J. A. Graves. 1999. Sex chromosomes and sex-determining genes: Insights from marsupials and monotremes. Cell. Mol. Life Sci. 55: 864–875.
PubMed Link

Peer, B. D. and R. W. Motz. 2014. Observations of a bilateral gynandromorph northern cardinal. Wilson J. Ornithol. 126: 778–781.

Pelttari, J. and 10 others. 2001. A meiotic chromosomal core consisting of cohesion complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells. Mol. Cell. Biol. 21: 5667–5677.
PubMed Link

Pfent, C., K. J. Pobursky, D. N. Sather and E. M. Golenberg. 2005. Characterization of SpAPETALA3 and SpPISTILLATA, B class floral identity genes in Spinacia oleracea, and their relationship to sexual dimorphism. Dev. Genes Evol. 215: 132–142.
PubMed Link

Pinkerton, J. H. M., D. G. McKay, E. C. Adams and A. T. Hertig. 1961. Development of the human ovary: A study using histochemical techniques. Obstet. Gynecol. 18: 152–181.

Pontiggia, A., R. Rimini, V. R. Harley, P. N. Goodfellow, R. Lovell-Badge and M. E. Bianchi. 1994. Sex-reversing mutations affect the architecture of Sry/DNA complexes. EMBO J. 13: 6115–6124.
PubMed Link

Pratt, S. A., N. F. Scully and B. D. Shur. 1993. Cell surface b-1,4-galactosyltransferase on primary spermatocytes facilitates their initial adhesion to Sertoli cells in vitro. Biol. Reprod. 49: 470–482.
PubMed Link

Qin, Y. and C. E. Bishop. 2005. Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry. Hum. Mol. Genet. 14: 1221–1229.
PubMed Link

Rahmoun, M. and 17 others. 2017. In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures. Nucleic Acids Res. 45: 7191–7211.
PubMed Link

Reijo, R. and 12 others. 1995. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat. Genet. 10: 383–393.
PubMed Link

Rey, R., N. Josso, and C. Racine C. 2016. Sexual differentiation. In L. J. De Groot et al. (eds.), Endotext [Internet]. MDText.com, Inc., South Dartmouth, MA.

Richardson, B. E. and R. Lehmann. 2010. Mechanisms guiding primordial germ cell migration: Strategies from different organisms. Nat. Rev. Mol. Cell Biol. 11: 37–49.
PubMed Link

Rideout, E. J., M. S. Narsaiya and S. S. Grewal. 2015. The sex determination gene transformer regulates male-female differences in Drosophila body size. PLOS Genet. 11: e1005683.
PubMed Link

Roberts, H. F. 1929. Plant Hybridization before Mendel. Princeton University Press, Princeton, NJ.

Ronai, I., V. Vergoz, and B. P. Oldroyd. 2016. The mechanistic, genetic and evolutionary basis of worker sterility in the social Hymenoptera. Adv. Stud. Behav. 48: 251–317.

Ryner, L. C. and B. S. Baker. 1991. Regulation of doublesex pre-mRNA processing occurs by 3′ splice site activation. Genes Dev. 5: 2071–2085.
PubMed Link

Saga, Y. 2008. Mouse germ cell development during embryogenesis. Curr. Opin. Genet. Dev. 18: 337–341.
PubMed Link

Saitou, M. and M. Yamaji. 2012. Primordial germ cells in mice. Cold Spring Harb. Perspect. Biol. 4: a008375.
PubMed Link

Sakuno, T. and Y. Watanabe. 2009. Studies of meiosis disclose distinct roles of cohesion in the core centromere and pericentromeric regions. Chromosome Res. 17: 239–249.
PubMed Link

Salz, H. K. 2011. Sex determination in insects: A binary decision based on alternative splicing. Curr. Opin. Genet. Dev. 21: 395–400.
PubMed Link

Scherthan, H. 2007. Telomere attachment and clustering during meiosis. Cell Mol. Life Sci. 64: 117–124.
PubMed Link

Schmerler. S. and G. M. Wessel. 2011. Polar bodies: More a lack of understanding than a lack of respect. Mol. Reprod. Dev. 78: 3–8.
PubMed Link

Schöckel, L., M. Möckel, B. Mayer, D. Boos and O. Stemmann. 2011. Cleavage of cohesin rings coordinates the separation of centrioles and chromatids. Nat. Cell Biol. 13: 966–972.
PubMed Link

Schuh, M. and J. Ellenberg. 2008. A new model for asymmetric spindle positioning in mouse oocytes. Curr. Biol. 18: 1986–1992.
PubMed Link

Schwarz-Sommer, Z., P. Huijser, W. Nacken, H. Saedler and H. Sommer. 1990. Genetic control of flower development by homeotic genes in Antirrhinum majus. Science 250: 931–936.
PubMed Link

Sekido, R. and R. Lovell-Badge. 2008. Sex determination involves synergistic action of Sry and Sf1 on a specific Sox9 enhancer. Nature 453: 930–934.
PubMed Link

Sekido, R. and R. Lovell-Badge. 2009. Sex determination and SRY: Down to a wink and a nudge? Trends Genet. 25: 19–29.
PubMed Link

Sekido, R., I. Bar, V. Narvárez, G. Penny and R. Lovell-Badge. 2004. SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev. Biol. 274: 271–279.
PubMed Link

Severance, A. L. and K. E. Latham. 2018. Meeting the meiotic challenge: Specializations in mammalian oocyte spindle formation. Mol. Reprod. Dev. 85: 178–187
PubMed Link.

Severson, A. F., G. von Dassow and B. Bowerman. 2016. Oocyte meiotic spindle assembly and function. Curr. Top. Dev. Biol. 116: 65–98.
PubMed Link

Shoemaker, C. M., J. Queen, and D. Crews. 2007. Response of candidate sex-determining genes to changes in temperature reveals their involvement in the molecular network underlying temperature-dependent sex determination. Mol. Endocrinol. 21: 2750–2763.
PubMed Link

Siiteri, P. K. and J. D. Wilson. 1974. Testosterone formation and metabolism during male sexual differentiation in the human embryo. J. Clin. Endocrinol. Metabol. 38: 113–125.
PubMed Link

Siu, M. K. Y. and C. Y. Cheng. 2004. Dynamic cross-talk between cells and the extracellular matrix in the testis. BioEssays 26: 978–992.
PubMed Link

Smith, C. A. and A. H. Sinclair. 2001. Sex determination in the chicken embryo. J. Exp. Zool. 290: 691–699.
PubMed Link

Smith, C. A., K. N. Roeszler, T. Ohnesorg, D. M. Cummins, P. G. Farlie, T. J. Doran and A. H. Sinclair. 2009. The avian Z-linked gene DMRT1 is required for male sex determination in the chicken. Nature 461: 267–271.
PubMed Link

Song, H. W. and M. F. Wilkinson. 2014. Transcriptional control of spermatogonial maintenance and differentiation. Semin. Cell Dev. Biol. 30: 14–26.
PubMed Link

Song, S., T. Qi, H. Huang, and D. Xie. 2013. Regulation of stamen development by coordinated actions of jasmonate, auxin, and gibberellin in Arabidopsis. Mol. Plant 6: 1065–1073.
PubMed Link

Stanford, C. B. and many others. 2020. Turtles and tortoises are in trouble. Current Biol. 30: R721–R735.
PubMed Link

Stévant, I. and S. Nef. 2019. Genetic control of gonadal sex determination and development. Trends Genet. 35: 346–358.
PubMed Link

Stevens, N. M. 1905. Studies in Spermatogenesis with Especial Reference to the “Accessory Chromosome.” Publication 36. Carnegie Institution of Washington, Washington, DC.

Susaki, D., Suzuki, T., Maruyama, D., et al. 2021. Dynamics of the cell fate specifications during female gametophyte development in Arabidopsis. PLoS Biol. 19(3): e3001123.
PubMed Link

Suskin, A. 2002. Bet you didn’t know... what the Talmud says about gender identity. Lilith.
Link

Tanaka, S. S. and R. Nishinakamura. 2014. Regulation of male sex determination: Genital ridge formation and Sry activation in mice. Cell. Mol. Life Sci. 71: 4781–4802.
PubMed Link

Tanaka, S. S., Y. L. Yamaguchi, B. Rsoi, H. Lickert and P. P. Tam. 2005. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev. Cell 9: 745–756.
PubMed Link

Taracena, M. L., C. M. Hunt, M. Q. Benedict, P. M. Pennington and E. M. Dotson. 2019. Downregulation of female Doublesex expression by oral-mediated RNA interference reduces number and fitness of Anopheles gambiae adult females. Parasite Vectors 12: 170.
PubMed Link

Tarbashevich, K. and E. Raz. 2010. The nuts and bolts of germ-cell migration. Curr. Opin. Cell Biol. 22: 715–721.
PubMed Link

Theisssen, G., R. Melzer and F. Rümpler. 2016. MADS-domain transcription factors and the floral quartet model of flower development: linking plant development and evolution. Development 143: 3259–3271.
PubMed Link

Thigpen, A. E., D. L. Davis, T. Gautier, J. Imperato-McGinley and D. W. Russell. 1992. The molecular basis of steroid 5a-reductase deficiency in a large Dominican kindred. N. Engl. J. Med. 327: 1216–1219.
PubMed Link

Tiwari, M. and S. K. Chaube. 2017. Maturation promoting factor destabilization mediates human chorionic gonadotropin induced meiotic resumption in rat oocytes. Dev. Growth Differ. 59: 603–614.
PubMed Link

Tokue, M. and 18 others. 2017. SHISA6 confers resistance to differentiation-promoting Wnt/β-catenin signaling in mouse spermatogenic stem cells. Stem Cell Rep. 8: 561–575.
PubMed Link

Tsai, J. H. and B. D. McKee. 2011. Homologous pairing and the role of pairing centers in meiosis. J. Cell Sci. 124: 1955–1963.
PubMed Link

Uraji, J., K. Scheffler and M. Schuh. 2018. Functions of actin in mouse oocytes at a glance. J Cell Sci. 131(22): jcs218099.
PubMed Link

Valverde, F., A. Mouradov, W. Soppe, D. Ravenscroft, A. Samach, and G. Coupland. 2004. Photoreceptor regulation of CONSTANS protein in photoperiodic flowering. Science 303: 1003–1006.
PubMed Link

Verhulst, E. C. and L. van der Zande. 2015. Double nexus—Doublesex is the connecting element in sex determination. Brief. Funct. Genomics 14: 396–406.
PubMed Link

Vidal, V. P. I., M.-C. Chaboissier, D. G. de Rooij and A. Schedl. 2001. Sox9 induces testis development in XX transgenic mice. Nat. Genet. 28: 216–217.
PubMed Link

Villeneuve, A. M. and K. J. Hillers. 2001. Whence meiosis? Cell 106: 647–650.
PubMed Link

von Wettstein, D. 1984. The synaptonemal complex and genetic segregation. In C. W. Evans and H. G. Dickinson (eds.), Controlling Events in Meiosis. Cambridge University Press, Cambridge, 195–231.

Weber, C., Y. Zhou, J. G. Lee, L. L. Looger, G. Qian, C. Ge and B. Capel. 2020. Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b. Science 368: 303–306.
PubMed Link

Wei, Y. and 10 others. 2020. Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells. Mol Cell Biochem. doi: 10.1007/s11010-020-03977-3.
PubMed Link

Werner, M. H., J. R. Huth, A. M. Groneborn and G. M. Clore. 1995. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY–DNA complex. Cell 81: 705–714.
PubMed Link

Wigge, P. A., M. C. Kim, K. E. Jaeger, W. Busch, M. Schmid, J. U. Lohmann and D. Weigel. 2005. Integration of spatial and temporal information during floral induction in Arabidopsis. Science 309: 1056–1059.
PubMed Link

Wilhelm, D., L. L. Washburn, V. Truong, M. Fellous, E. M. Eicher and P. Koopman. 2009. Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech. Dev. 126: 324–336.
PubMed Link

Wilson, E. B. 1905. The chromosomes in relation to the determination of sex in insects. Science 22: 500–502.

Wilson, E. B. 1924. The Cell in Development and Heredity, 3rd Ed. Macmillan, New York.

Wynne, D. J., O. Rog, P. M. Carlton and A. F. Dernburg. 2012. Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis. J. Cell Biol. 196: 47–64.
PubMed Link

Xie, B. and 11 others. 2018. Poly(ADP-ribose) mediates asymmetric division of mouse oocyte. Cell Res. 28: 462–475.
PubMed Link

Yamaguchi, S. and 7 others. 2012. Tet1 controls meiosis by regulating meiotic gene expression. Nature 492: 443–447.
PubMed Link

Yang, J. H., J. Menshenina, G. R. Cunha, N. Place and L. S. Baskin. 2010. Morphology of mouse external genitalia: Implications for a role of estrogen in sexual dimorphism of the mouse genital tubercle. J. Urol. 184(4 Suppl):1604–1609.
PubMed Link

Yanovsky, M. J. and S. A. Kay. 2002. Molecular basis of seasonal time measurement in Arabidopsis. Nature 419: 308–312.
PubMed Link

Yoshida, S. 2016. From cyst to tubule: Innovations in vertebrate spermatogenesis. Wiley Interdiscip. Rev. Dev. Biol. 5: 119–131.
PubMed Link

Yoshida, S., M. Sukeno and Y. Nabeshima. 2007. A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science 317: 1722–1726.
PubMed Link

Zhang, B. and X. Chen. 2021. Secrets of the MIR172 family in plant development and flowering unveiled. PLoS Biol. 19:e3001099.
PubMed Link

Zhang, J., M. Zhang, D. Acampora, M. Vojtak, D. Yuan, A. Simeone and I. Chambers. 2018.. OTX2 restricts entry to the mouse germline. Nature 562: 595–599.
PubMed Link

Zhao, D., D. and 8 others. 2010. Somatic sex identity is cell-autonomous in the chicken. Nature 464: 237–242.
PubMed Link

Zhao, F., H. L. Franco, K. F. Rodriguez, P. R. Brown, M. J. Tsai, S. Y. Tsai, and H. H. Yao. 2017. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science 357: 717–720.
PubMed Link

Zickler, D. and N. Kleckner. 2015. Recombination, pairing, and synapsis of homologs during meiosis. Cold Spring Harb. Perspect. Biol. 7: a016626.
PubMed Link

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