Adamska, M. 2018. Differentiation and transdifferentiation of sponge cells. Results Probl. Cell Differ. 65: 229–253.
PubMed Link
Adler, C. E. and A. Sánchez Alvarado. 2015. Types or states? Cellular dynamics and regenerative potential. Trends Cell Biol. 25: 687–696.
PubMed Link
Apte, U. and 10 others. 2009. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 50: 844–85.
PubMed Link
Baguñà, J. 2012. The planarian neoblast: The rambling history of its origin and some current black boxes. Int. J. Dev. Biol. 56: 19–37.
PubMed Link
Beane, W. S., J. Morokuma, D. S. Adams and M. Levin. 2011. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem. Biol. 18: 77–89.
PubMed Link
Bennett, T., G. Hines and O. Leyser. 2014. Canalization: What the flux? Trends Genet. 30: 41–48.
PubMed Link
Birkholz, T. R., A. V. Van Huizen and W. S. Beane. 2018. Staying in shape: Planarians as a model for understanding regenerative morphology. Semin. Cell Dev. Biol. 87: 105–115.
PubMed Link
Birnbaum, K. D. and A. Sánchez Alvarado. 2008. Slicing across kingdoms: Regeneration in plants and animals. Cell 132: 697–710.
PubMed Link
Bode, H. R. 2009. Axial patterning in Hydra. Cold Spring Harbor Persp. Biol. 1: a000463.
PubMed Link
Bode, H. R. 2011. Axis formation in hydra. Annu. Rev. Genet. 45: 105–117.
PubMed Link
Borisenko, I. E., M. Adamska, D. B. Tokina and A. V. Ereskovsky. 2015. Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera). Peer J. 3: e1211.
PubMed Link
Brockes, J. P. and A. Kumar. 2002. Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nat. Rev. Mol. Cell Biol. 3: 566–574.
PubMed Link
Broun, M. and H. R. Bode. 2002. Characterization of the head organizer in hydra. Development 129: 875–884.
PubMed Link
Broun, M., L. Gee, B. Reinhardt and H. R. Bode. 2005. Formation of the head organizer in hydra involves the canonical Wnt pathway. Development 132: 2907–2916.
PubMed Link
Broun, M., S. Sokol and H. R. Bode. 1999. Cngsc, a homologue of goosecoid, participates in the patterning of the head and is expressed in the organizer region of Hydra. Development 126: 5245–5254.
PubMed Link
Browne, E. N. 1909. The production of small hydranths in hydra by insertion of small grafts. J. Exp. Zool. 7: 1–23.
Link
Bryant, S. 1999. A regeneration renaissance. Semin. Cell Dev. Biol. 10: 313.
Butler, E. G. 1935. Studies on limb regeneration in X-rayed Ambystoma larvae. Anat. Rec. 62: 295–307.
Buzgariu, W., M. Crescenzi and B. Galliot. 2014. Robust G2 pausing of adult stem cells in Hydra. Differentiation 87: 83–99.
PubMed Link
Campbell, R. D. 1967a. Tissue dynamics of steady state growth in Hydra littoralis. I. Patterns of cell division. Dev. Biol. 15: 487–502.
PubMed Link
Campbell, R. D. 1967b. Tissue dynamics of steady state growth in Hydra littoralis. II. Patterns of tissue movement. J. Morphol. 121: 19–28.
PubMed Link
Chera, S., L. and 7 otheres. 2009. Apoptotic cells provide an unexpected source of Wnt3 signaling to drive Hydra head regeneration. Dev. Cell 17: 279–289.
PubMed Link
Chernoff, E. A. G. and D. Stocum. 1995. Developmental aspects of spinal cord and limb regeneration. Dev. Growth Diff. 37: 133–147.
Link
Child, C. M. 1905. Studies on regulation. VII. Further experiments on form regulation in Leptoplana. J. Exp. Zool. 2: 253–285.
Costa, A., J. D. Naranjo, R. Londono and S. F. Badylak. 2017. Biologic scaffolds. Cold Spring Harb. Perspect. Med. 7: a025676.
PubMed Link
Crawford, K. and D. L. Stocum. 1988. Retinoic acid proximalizes level-specific properties responsible for intercalary regeneration in axolotl limbs. Development 104: 703–712.
PubMed Link
De Mulder, K., and 10 others. 2009. Characterization of the stem cell system of the acoel Isodiametra pulchra. BMC Dev. Biol. 9: 69.
PubMed Link
Del Rio-Tsonis, K., C. H. Washabaugh and P. A. Tsonis. 1995. Expression of Pax-6 during urodele eye development and lens regeneration. Proc Natl Acad Sci USA 92: 5092–5096.
PubMed Link
Dinsmore, C. E. (ed.). 1991. A History of Regeneration Research: Milestones in the Evolution of a Science. Cambridge University Press, New York.
Eerkes‐Medrano, D., C. J. Feehan and S. P. Leys. 2015. Sponge cell aggregation: Checkpoints in development indicate a high level of organismal complexity. Invert. Biol. 134: 1–18.
Link
Eguchi, G. 1963. Electron microscopic studies on lens regeneration. I. epigmentation of the iris. Embryologia 8: 45–62.
Link
Eguchi, G. 1964. Electron microscopic studies on lens regeneration. II. Formation and growth of lens vesicle and differentiation of lens fibers. Embryologia 8: 247–287.
Link
Eguchi, G., Y. Eguchi, K. Nakamura, K., M. C. Yadav, J. L. Millan and P. A. Tsonis. 2011. Regenerative capacity in newts is not altered by repeated regeneration and ageing. Nat. Commun. 2: 384.
Link
Endo, T., S. V. Bryant and D. M. Gardiner. 2004. A stepwise model system for limb regeneration. Dev. Biol. 270: 135–145.
PubMed Link
Ereskovsky, A. V., I. E. Borisenko, P. Lapébie, E. Gazave, D. B. Tokina and C. Borchiellini. 2015. Oscarella lobularis (Homoscleromorpha, Porifera) regeneration: Epithelial morphogenesis and metaplasia. PLoS ONE 10: 1–19.
PubMed Link
Ereskovsky, A. V., A. I. Lavrov, F. V. Bolshakov and D. B. Tokina. 2017. Regeneration in white sea sponge Leucosolenia complicata (Porifera, Calcarea). Invert. Zool. 14: 108–113.
Link
Farkas, J. E. and J. R. Monaghan. 2017. A brief history of the study of nerve-dependent regeneration. Neurogenesis 4: e1302216.
PubMed Link
Farkas, J. E., P. D. Freitas, D. M. Bryant, J. L. Whited and J. R. Monaghan. 2016. Neuregulin-1 signaling is essential for nerve-dependent axolotl limb regeneration. Development 143: 2724–2731.
PubMed Link
Farrell, J. A., Y. Wang, S. J. Riesenfeld, K. Shekhar, A. Regev and A. F. Schier. 2018. Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis. Science 360:eaar3131.
PubMed Link
Fausto, N. and J. S. Campbell. 2005. The role of hepatocytes and oval cells in liver regeneration. Mech. Dev. 120: 117–130.
PubMed Link
Funayama, N. 2018. The cellular and molecular bases of the sponge stem cell systems underlying reproduction, homeostasis and regeneration. Int. J. Dev. Biol. 62: 513–525.
PubMed Link
Gardiner, D. M., T. Endo and S. V. Bryant. 2002. The molecular basis of amphibian limb regeneration: Integrating the old with the new. Semin. Cell Dev. Biol. 13: 345–352.
PubMed Link
Gatza, C., L. Moore, M. Dumble and L. A. Donehower. 2007. Tumor suppressor dosage regulates stem cell dynamics during aging. Cell Cycle 6: 52–55.
PubMed Link
Gawriluk, T. R. and 9 others. 2016. Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals. Nat. Commun. 7: 11164.
PubMed Link
Gee, L., J. Hartig, L. Law, J. Wittlieb, K. Khalturin, T. C. Bosch and H. R. Bode. 2010. Beta-catenin plays a central role in setting up the head organizer in Hydra. Dev. Biol. 340: 116–124.
PubMed Link
Gentile, L., F. Cebrià, and K. Bartscherer. 2011. The planarian flatworm: An in vivo model for stem cell biology and nervous system regeneration. Disease Models Mech. 4: 12–19.
PubMed Link
Gerber, T. and 13 others. 2018. Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Science 362:eaaq0681.
PubMed Link
Gierer, A., S. and 7 others. 1972. Regeneration of Hydra from reaggregated cells. Nat. New Biol. 239: 98–101.
PubMed Link
Gilgenkrantz, H. and A. C. de l'Hortet A. 2018. Understanding liver regeneration: From mechanisms to regenerative medicine. Am. J. Pathol. 188: 1316–1327.
PubMed Link
Gkretsi, V., W. C. Bowen, Y. Yang, C. Wu and G. K. Michalopoulos. 2007. Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Biochem Biophys Res Commun. 353: 638–643.
PubMed Link
Gkretsi, V. and 11 others. 2008. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 48: 1932–1941.
PubMed Link
Godwin, J. W., A. R. Pinto and N. A. Rosenthal. 2013. Macrophages are required for adult salamander limb regeneration. Proc. Natl. Acad. Sci. USA 110: 9415–9420.
PubMed Link
Goss, R. J. 1969. Principles of Regeneration. Academic Press, New York.
Goss, R. J. 1991. The natural history (and mystery) of regeneration. In C. E. Dinsmore (ed.), A History of Regeneration Research. Cambridge University Press, Cambridge.
Gurley, K. A., J. C. Rink and A. Sánchez Alvarado. 2008. Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science 319: 323–327.
PubMed Link
Haas, B. J. and J. L. Whited. 2017. Advances in decoding axolotl limb regeneration. Trends Genet. 33: 553–565.
PubMed Link
Han, M. J., J. Y. An and W. S. Kim. 2001. Expression patterns of Fgf-8 during development and limb regeneration of the axolotl. Dev. Dyn. 220: 40–48.
PubMed Link
Herlands, R. and H. Bode. 1974. The influence of tissue polarity on nematocyte migration in Hydra attenuata. Dev. Biol. 40: 323–339.
PubMed Link
Higgins, G. M. and R. M. Anderson. 1931. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch. Pathol. 12: 186–202.
Hill, E. M. and C. P. Petersen. 2015. Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain. Development 142: 4217–4229.
PubMed Link
Hobmayer, B. and 7 others. 2000. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature 407: 186–189.
PubMed Link
Hu, C. K. and A. Brunet. 2018. The African turquoise killifish: A research organism to study vertebrate aging and diapause. Aging Cell 17: e12757.
PubMed Link
Huang, M. and 11 others. 2022. CC motif chemokin ligand-5 confines liver regeneration by downregulating reparative macrophage-derived HGF in an Forkhead Box O3a-dependent manner. Hepatology 76:1706–1722.
PubMed Link
Huang, S.-M. and 35 others. 2009. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461: 614–620.
PubMed Link
Huang, W. and 8 others. 2006. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312: 233–236.
PubMed Link
Iglesias, M., J. L. Gomez-Skarmeta, E. Saló and T. Adell. 2008. Silencing of Smed-b-catenin1 generates radial-like hypercephalized planarians. Development 135: 1215–1221.
PubMed Link
Johnson, K., J. Bateman, T. DiTommaso, A. Y. Wong and J. L. Whited. 2018. Systemic cell cycle activation is induced following complex tissue injury in axolotl. Dev. Biol. 433: 461–472.
PubMed Link
Jouannet, V., K. Brackmann and T. Greb. 2015. (Pro)cambium formation and proliferation: Two sides of the same coin? Curr. Opin. Plant Biol. 23: 54–60.
PubMed Link
Karasaki, S. 1964. An electron microscopic study of Wolffian lens regeneration in the adult newt. J. Ultrastruct. Res. 11: 246–273.
PubMed Link
Kareem, A., and 6 others. 2016a. De novo assembly of plant body plan: A step ahead of Deadpool. Regeneration 3: 182–197.
PubMed Link
Kareem, A. and 8 others. 2016b. Protocol: A method to study the direct reprogramming of lateral root primordia to fertile shoots. Plant Methods 12: 27.
PubMed Link
Kawakami, Y. and 6 others. 2006. Wnt/beta-catenin signaling regulates vertebrate limb regeneration. Genes Dev. 20: 3232–3237.
PubMed Link
Kim, G. H., T. A. Klotchkova and Y. M. Kang. 2001. Life without a cell membrane: Regeneration of protoplasts from disintegrated cells of the marine green alga Bryopsis plumosa. J. Cell Sci. 114: 2009–2014.
PubMed Link
Kim, T. H., W. M. Mars, D. B. Stolz, B. E. Petersen and G. K. Michalopoulos. 1997. Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology 26: 896–904.
PubMed Link
Knopf, F. and 10 others. 2011. Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev. Cell 20: 713–724.
PubMed Link
Kragl, M., D. Knapp, E. Nacu, S. Khattak, M. Maden, H. H. Epperlein and E. M. Tanaka. 2009. Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460: 60–65.
PubMed Link
Lander, R. and C. P. Petersen. 2016. Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration. eLife 5:e12850.
PubMed Link
Lengfeld, T., H. Watanabe, O. Simakov, D. Lindgens, L. Gee, L. Law, H. A. Schmidt, S. Ozbek, H. Bode and T. W. Holstein. 2009. Multiple Wnts are involved in Hydra organizer formation and regeneration. Dev. Biol. 330: 186–199.
PubMed Link
Lenhoff, H. M. 1991. Ethel Browne Harvey, Hans Spemann, and the discovery of the organizer phenomenon. Biol. Bull. 181: 72–80.
PubMed Link
Levin, M., G. Pezzulo and J. M. Finkelstein. 2017. Endogenous bioelectric signaling networks: Exploiting voltage gradients for control of growth and form. Annu. Rev. Biomed. Eng. 19: 353–387.
PubMed Link
Levin, M., A. M. Pietak and J. Bischof. 2018. Planarian regeneration as a model of anatomical homeostasis: Recent progress in biophysical and computational approaches. Semin. Cell Dev. Biol. 87: 125–144.
PubMed Link
Li, Q., H. Yang and T. P. Zhong. 2015. Regeneration across metazoan phylogeny: Lessons from model organisms. J. Genet. Genomics 42: 57–70.
PubMed Link
Li, S. 2015. The Arabidopsis thaliana TCP transcription factors: A broadening horizon beyond development. Plant Signal Behav. 10: e1044192.
PubMed Link
Lin, T.-Y. and 8 others. 2021. Fibroblast dedifferentiation as a determinant of successful regeneration. Dev. Cell 56: 1541–1551.e6.
PubMed Link
Liu, J., L. Sheng, Y. Xu, J. Li, Z. Yang, H. Huang and L. Xu. 2014. WOX11 and 12 are involved in the first-step cell fate transition during de novo root organogenesis in Arabidopsis. Plant Cell 26: 1081–1093.
PubMed Link
Liu, S.-Y. and 9 others. 2013. Reactivating head regrowth in a regeneration-deficient planarian species. Nature 500: 81–84.
PubMed Link
Londono, R. and S. F. Badylak. 2015. Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Ann. Biomed. Eng. 43: 577–592.
PubMed Link
MacWilliams, H. K. 1983. Hydra transplantation phenomena and the mechanism of Holm head regeneration. II. Properties of head activation. Dev. Biol. 96: 239–257.
PubMed Link
Maden, M. 1983. The effect of vitamin A on the regenerating axolotl limb. J. Embryol. Exp. Morph. 77: 273–95.
PubMed Link
Madhavan, M. and 6 others. 2006. The role of Pax-6 in lens regeneration. Proc. Natl. Acad. Sci. USA 103: 14848–14853.
PubMed Link
Makanae, A., K. Mitogawa and A. Satoh. 2014. Co-operative BMP and FGF signaling inputs convert skin wound healing to limb formation in urodele amphibians. Dev. Biol. 396: 57–66.
PubMed Link
Mandoli, D. F. 1998. Elaboration of body plan and phase change during development of Acetabularia: How is the complex architecture of a giant unicell built? Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 173–198.
PubMed Link
Mars, W. M., T. H. Kim, D. B. Stolz, M. L. Liu and G. K. Michalopoulos. 1996. Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res. 56: 2837–2843.
PubMed Link
Mazur, E., E. Benková and J. Friml. 2016. Vascular cambium regeneration and vessel formation in wounded inflorescence stems of Arabidopsis. Sci. Rep. 6: 33754.
PubMed Link
McCusker, C. D. and D. M. Gardiner. 2011. The axolotl model for regeneration and aging research: A mini-review. Gerontology 57: 565–571.
PubMed Link
McCusker, C. D. and D. M. Gardiner. 2014. Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies. Disease Models Mech. 7: 593–599.
PubMed Link
McCusker, C., J. Lehrberg and D. Gardiner. 2014. Position-specific induction of ectopic limbs in non-regenerating blastemas on axolotl forelimbs. Regeneration 1: 27–34.
PubMed Link
McLaughlin, K. A. and M. Levin. 2018. Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form. Dev. Biol. 433: 177–189.
PubMed Link
Michalopoulos, G. K. 2017. Hepatostat: Liver regeneration and normal liver tissue maintenance. Hepatology 5:1384–1392.
PubMed Link
Michalopoulos, G. K. and B. Bhushan. 2021. Liver regeneration: Biological and pathological mechanisms and implications. Nat. Rev. Gastroenterol. Hepatol. 18: 40–55.
PubMed Link
Mittman, G. and A. Fausto Sterling. 1992. Whatever happened to planaria? C.M. Child and the physiology of inheritance. In The Right Tools for the Job: At Work in Twentieth-Century Life Science. A. Clarke and J. Fujimara (eds.). Princeton University Press, Princeton, NJ.
Miyashima, S., J. Sebastian, J. Y. Lee and Y. Helariutta. 2013. Stem cell function during plant vascular development. EMBO J. 32: 178–193.
PubMed Link
Mizuno, N., M. Mochii, T. S. Yamamoto, T. C. Takahashi, G. Eguchi and T. S. Okada. 1999. Pax-6 and Prox 1 expression during lens regeneration from Cynops iris and Xenopus cornea: evidence for a genetic program common to embryonic lens development. Differentiation 65: 141–149.
PubMed Link
Moolten, F. L. and N. L. Bucher. 1967. Regeneration of rat liver: Transfer of humoral agent by cross circulation. Science 158: 272–274.
PubMed Link
Morgan, T. H. 1905. Regeneration. Macmillan, New York.
Morrison, J. I., S. Lööf, S. P. He and A. Simon. 2006. Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. J. Cell Biol. 172: 433–440.
PubMed Link
Mullen, L. M., S. V. Bryant, M. A. Torok, B. Blumberg and D. M. Gardiner. 1996. Nerve dependency of regeneration: The role of Distal-less and FGF signaling in amphibian limb regeneration. Development 122: 3487–3497.
PubMed Link
Murugan, N. J. and 9 others. 2022. Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis. Sci. Adv. 8:eabj2164.
PubMed Link
Nacu, E., and E. M. Tanaka. 2011. Limb regeneration: A new development? Annu. Rev. Cell Dev. Biol. 27: 409–440.
PubMed Link
Nejak-Bowen, K., A. Orr, W. C. Bowen Jr. and G. K. Michalopoulos. 2013. Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy. PLoS ONE 8, e59836.
PubMed Link
Newman, S. A. 1974. The interaction of the organizing regions of hydra and its possible relation to the role of the cut end of regeneration. J. Embryol. Exp. Morphol. 31: 541–555.
PubMed Link
Newmark, P. A. and A. Sánchez Alvarado. 2000. Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev. Biol. 220: 142–153.
PubMed Link
Niazi, I. A., M. J. Pescitelli and D. L. Stocum. 1985. Stage-dependent effects of retinoic acid on regenerating urodele limbs. W. Roux Archiv fur Entwicklungsmechanik. 194: 355–363.
Link
Oviedo, N. J. and W. S. Beane. 2009. Regeneration: The origin of cancer or a possible cure?. Semin. Cell Dev. Biol. 20: 557–564.
PubMed Link
Pai, V. P., C. J. Martyniuk, K. Echeverri, S. Sundelacruz, D. L. Kaplan and M. Levin. 2015. Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation. Regeneration 3: 3–25.
PubMed Link
Pallas, P. S. 1766. Miscellanea zoologica, quibus novae imprimis atque obscurae animalium species Hagae Comitum. Apud Pterum van Cleef, Holland.
Payzin-Dogru, D. and J. L. Whited. 2018. An integrative framework for salamander and mouse limb regeneration. Int. J. Dev. Biol. 62: 393–402.
PubMed Link
Pearson, B. J. and A. Sánchez Alvarado. 2009. Regeneration, stem cells, and the evolution of tumor suppression. Cold Spring Harb. Symp. Quant. Biol. 73: 565–572.
PubMed Link
Pellettieri, J. and A. Sánchez Alvarado. 2007. Cell turnover and adult tissue homeostasis: From humans to planarians. Annu. Rev. Genet. 41: 83–105.
PubMed Link
Pellettieri, J., P. Fitzgerald, S. Watanabe, J. Mancuso, D. R. Green and A. Sánchez Alvarado. 2010. Cell death and tissue remodeling in planarian regeneration. Dev. Biol. 338: 76–85.
PubMed Link
Petersen, C. P. and P. W. Reddien. 2008. Smed-beta catenin-1 is required for anteroposterior blastema polarity in planarian regeneration. Science 319: 327–330.
PubMed Link
Petersen, C. P. and P. W.Reddien. 2009. A wound-induced Wnt expression program controls planarian regeneration polarity. Proc Natl Acad Sci USA106: 17061–17066.
PubMed Link
Petersen, C. P. and P. W. Reddien. 2011. Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration. Science 332: 852–855.
PubMed Link
Petrie, T.A., N. S. Strand, C. T. Yang, J. S. Rabinowitz and R. T. Moon. 2014. Macrophages modulate adult zebrafish tail fin regeneration. Development 141: 2581–2591.
PubMed Link
Raz, A. A., M. Srivastava, R. Salvamoser and P. W. Reddien. 2017. Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning. Nat. Commun. 8: 1260.
PubMed Link
Reddien, P. W. 2011. Constitutive gene expression and the specification of tissue identity in adult planarian biology. Trends Genet. 27: 277–285.
PubMed Link
Reddien, P. W. 2013. Specialized progenitors and regeneration. Development 140: 951–957.
PubMed Link
Reddien, P. W. 2018. The cellular and molecular basis for planarian regeneration. Cell 175: 327–345.
PubMed Link
Reddien, P. W. 2021. Positional information and stem cells combine
to result in planarian regeneration. Cold Spring Harb. Perspect. Biol. 13: a040717.
PubMed Link
Reddien, P. W., N. J. Oviedo, J. R. Jennings, J. C. Jenkin and A. Sánchez Alvarado. 2005. SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science 310: 1327–1330.
PubMed Link
Reyer, R. 1990. Macrophage invasion and phagocytic activity during lens regeneration from the iris epithelium in newts. Am. J. Anat. 188: 329–344.
PubMed Link
Riehle, K. J., Y. Y. Dan, J. S. Campbell and N. Fausto. 2011. New concepts in liver regeneration. J. Gastroenterol. Hepatol. 1: 203–212.
PubMed Link
Rink, J. C. 2018. Stem cells, patterning and regeneration in planarians: Self-organization at the organismal scale. Methods Mol. Biol. 1774: 57–172.
PubMed Link
Roberts-Galbraith, R. H. and P. A. Newmark. 2015. On the organ trail: Insights into organ regeneration in the planarian. Curr. Opin. Genet. Dev. 32: 37–46.
PubMed Link
Rudolph, K. L. and 7 others. 1999. Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats. Hepatology 5: 1159–1166.
PubMed Link
Satoh, A., K. Mitogawa and A. Makanae. 2015. Regeneration inducers in limb regeneration. Dev. Growth Differ. 57: 421–429.
PubMed Link
Scimone, M. L., L. E. Cote, T. Rogers and P. W. Reddien. 2016. Two FGFRL-Wnt circuits organize the planarian anteroposterior axis. eLife 5: e12845.
PubMed Link
Scimone, M. L., L. E. Cote and P. W. Reddien. 2017. Orthogonal muscle fibres have different instructive roles in planarian regeneration. Nature 551: 623–628.
PubMed Link
Seifert, A. W. and K. Muneoka. 2018. The blastema and epimorphic regeneration in mammals. Dev. Biol. 433: 190–199.
PubMed Link
Seifert, A. W., S. G. Kiama, M. G. Seifert, J. R. Goheen, T. M. Palmer and M. Maden. 2012. Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature 489: 561–565.
PubMed Link
Shi, W., Z. Fang, L. Li and L. Luo. 2015. Using zebrafish as the model organism to understand organ regeneration. Sci. China Life Sci. 58: 343–351.
PubMed Link
Shimotohno, A., R. Heidstra, I. Blilou and B. Scheres. 2018. Root stem cell niche organizer specification by molecular convergence of PLETHORA and SCARECROW transcription factor modules. Genes Dev. 32: 1085–1100.
PubMed Link
Sidman, R. L. and M. Singer. 1951. Stimulation of forelimb regeneration in the newt, Triturus viridescens, by a sensory nerve supply isolated from the central nervous system. Am. J. Physiol. 165: 257–260.
PubMed Link
Sidman, R. L. and M. Singer. 1960. Limb regeneration without innervation of the apical epidermis in the adult newt, Triturus. J. Exp. Zool. 144: 105–110.
Siebert, S. and 6 others. 2019. Stem cell differentiation
trajectories in Hydra resolved at single-cell resolution. Science 365: eaav9314.
PubMed Link
Sikes, J. M. and P. A. Newmark. 2013. Restoration of anterior regeneration in a planarian with limited regenerative ability. Nature 500: 77–80.
PubMed Link
Simkin, J., T. R. Gawriluk, J. C. Gensel and A. W. Seifert. 2017. Macrophages are necessary for epimorphic regeneration in African spiny mice. eLife 6:e24623.
PubMed Link
Simon, A. and E. M. Tanaka. 2013. Limb regeneration. Wiley Interdiscip. Rev. Dev. Biol. 2: 291–300.
PubMed Link
Simon, H. G., C. Nelson, D. Goff, E. Laufer, B. A. Morgan and C. Tabin. 1995. The differential expression of myogenic regulatory genes and msx-1 during dedifferentiation and redifferentiation of regenerating amphibian limbs. Dev. Dyn. 202: 1–12.
PubMed Link
Singer, M. 1946. The nervous system and regeneration of the forelimb of adult Triturus; the stimulating action of a regenerated motor supply. J. Exp. Zool. 101: 221–239.
PubMed Link
Singer, M. 1952. The influence of the nerve in regeneration of the amphibian extremity. Q. Rev. Biol. 27: 169–200.
PubMed Link
Singer, M. 1954. Induction of regeneration of the forelimb of the postmetamorphic frog by augmentation of the nerve supply. J. Exp. Zool. 126: 419–472.
Singer, M. and J. D. Caston. 1972. Neurotrophic dependence of macromolecular synthesis in the early limb regenerate of the newt, Triturus. J. Embryol. Exp. Morphol. 28: 1–11.
PubMed Link
Singer, M. and L. Craven. 1948.The growth and morphogenesis of the regenerating forelimb of adult Triturus following denervation at various stages of development. J. Exp. Zool. 108: 279–308.
PubMed Link
Singh, B. N., N. Koyano-Nakagawa, A. Donaldson, C. V. Weaver, M. G. Garry and D. J. Garry. 2015. Hedgehog signaling during appendage development and regeneration. Genes 6: 417–435.
PubMed Link
Singh, S. P., J. E. Holdway and K. D. Poss. 2012. Regeneration of amputated zebrafish fin rays from de novo osteoblasts. Dev. Cell 22: 879–886.
PubMed Link
Skoog, F. and C. O. Miller. 1957. Chemical regulation of growth and organ formation in plant tissues cultured in vitro. Symp. Soc. Exp. Biol. 11: 118–130.
PubMed Link
Sousounis, K., M. Looso, N. Maki, C. J. Ivester, T. Braun and P.A. Tsonis. 2013. Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns. PLoS One 8: e61445.
PubMed Link
Sousounis, K. and 6 others. 2014. Molecular signatures that correlate with induction of lens regeneration in newts: lessons from proteomic analysis. Hum. Genomics 8: 22.
PubMed Link
Srivastava, M., K. L. Mazza-Curll, J. C. van Wolfswinkel and P. W. Reddien. 2014. Whole-body acoel regeneration is controlled by Wnt and Bmp-Admp signaling. Curr. Biol. 24: 1107–1113.
PubMed Link
Steward, F. C., M. O. Mapes and K. Mears. 1958. Growth and organized development of cultured cells. II. Organization in cultures grown from freely suspended cells. Am. J. Bot. 45: 705–708.
Stewart, S. and K. Stankunas. 2012. Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration. Dev. Biol. 365: 339–349.
PubMed Link
Stoick-Cooper, C. L., G. Weidinger, K. J. Riehle, C. Hubbert, M. B. Major, N. Fausto and R. T. Moon. 2007. Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development 134: 479–489.
PubMed Link
Su, Y. H. and X. S. Zhang. 2014. The hormonal control of regeneration in plants. Curr. Top. Dev. Biol. 108: 35–69.
PubMed Link
Sugimoto, K., Y. Jiao and E. M. Meyerowitz. 2010. Arabidopsis regeneration from multiple tissues occurs via a root development pathway. Dev. Cell 18: 463–471.
PubMed Link
Sundelacruz, S., M. Levin and D. L. Kaplan. 2013. Depolarization alters phenotype, maintains plasticity of predifferentiated mesenchymal stem cells. Tissue Eng. 19A: 1889–1908.
PubMed Link
Sunderland, M. E. 2010. Regeneration: Thomas Hunt Morgan’s window into development. J. Hist. Biol. 43: 325–361.
PubMed Link
Tanaka, E. and P. W. Reddien. 2011. The cellular basis for animal regeneration. Dev. Cell 21: 172–185.
PubMed Link
Taub, R. 2004. Liver regeneration: From myth to mechanism. Nat. Rev. Mol. Cell Biol. 5: 836–847.
PubMed Link
Technau, U., C. Cramer von Laue, F. Rentzsch, S. Luft, B. Hobmayer, H. R. Bode and T. W. Holstein. 2000. Parameters of self-organization in Hydra aggregates. Proc. Natl. Acad. Sci. USA 97: 12127–12131.
PubMed Link
Todd, T. J. 1823. On the process of reproduction of the members of the aquatic salamander. Q. J. Sci. Lit. Arts 16: 84–96.
Tseng, A. and M. Levin. 2013. Cracking the bioelectric code: Probing endogenous ionic controls of pattern formation. Commun. Integr. Biol. 6: e22595.
PubMed Link
Umesono, Y. and 9 others. 2013. The molecular logic for planarian regeneration along the anterior-posterior axis. Nature 500: 73–76.
PubMed Link
Vasil, V. and A. C. Hildebrandt. 1965. Differentiation of tobacco plants from single, isolated cells in microcultures. Science 150: 889–892.
PubMed Link
Vergara, M. N., G. Tsissios and K. Del Rio-Tsonis. 2018. Lens regeneration: A historical perspective. Int. J. Dev. Biol. 62: 351–361.
PubMed Link
Wagner, D. E., I. E. Wang and P. W. Reddien. 2011. Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332: 811–816.
PubMed Link
Wang, W. and 15 others. 2020. Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates. Science 369: eaaz3090.
PubMed Link
Wehner, D. and 11 others. 2014. Wnt/b-catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin. Cell Rep. 6: 467–481.
PubMed Link
Wehner, D. and G. Weidinger. 2015. Signaling networks organizing regenerative growth of the zebrafish fin. Trends Genet. 31: 336–343.
PubMed Link
Wenemoser, D., S. W. Lapan, A. W. Wilkinson, G. W. Bell and P. W. Reddien. 2012. A molecular wound response program associated with regeneration initiation in planarians. Genes Dev. 26: 988–1002.
PubMed Link
White, P., J. E. Brestelli, K. H. Kaestner and L. E. Greenbaum. 2005. Identification of transcriptional networks during liver regeneration. J. Biol. Chem. 280: 3715–3722.
PubMed Link
Whited, J. L. and C. J. Tabin. 2009. Limb regeneration revisited. J. Biol. 8: 5.
PubMed Link
Wilby, O. K. and G. Webster. 1970. Experimental studies on axial polarity in hydra. J. Embryol. Exp. Morphol. 24: 595–613.
PubMed Link
Wilson, H. V. 1907. On some phenomena of coalescence and regeneration in sponges. J. Exp. Zool. 5: 245–258.
Link
Witchley, J. N., M. Mayer, D. E. Wagner, J. H. Owen and P. W. Reddien. 2013. Muscle cells provide instructions for planarian regeneration. Cell Rep. 4: 633–641.
PubMed Link
Wurtzel, O., L. E. Cote, A. Poirier, R. Satija, A. Regev and P. W. Reddien. 2015. A generic and cell-type-specific wound response precedes regeneration in planarians. Dev. Cell 35: 632–645.
PubMed Link
Xu, J., H. Hofhuis, R. Heidstra, M. Sauer, J. Friml and B. Scheres. 2006. A molecular framework for plant regeneration. Science 311: 385–388.
PubMed Link
Yamada, T. and D. McDevitt. 1974. Direct evidence for transformation of differentiated iris epithelial cells into lens cells. Dev. Biol. 38: 104–118.
PubMed Link
Yasuda, K. 2004. A life in research on lens regeneration and transdifferentiation. An interview with Goro Eguchi. Int. J. Dev. Biol. 48: 695–700.
PubMed Link
Yin, V. P. and K. D. Poss. 2008. New regulators of vertebrate appendage regeneration. Curr. Opin. Genet. Dev. 18: 381–386.
PubMed Link
Yun, M. H., H. Davaapil and J. P. Brockes. 2015. Recurrent turnover of senescent cells during regeneration of a complex structure. eLife 4: e05505.
PubMed Link
Zhong, Z., L. Yang, Y. E. Zhang, Y. Xue and S. He. 2016. Correlated expression of retrocopies and parental genes in zebrafish. Mol. Genet. Genomics 291: 723–737.
PubMed Link
Zhu, S. J. and B. J. Pearson. 2016. (Neo)blast from the past: New insights into planarian stem cell lineages. Curr. Opin. Genet. Dev. 40: 74–80.
PubMed Link