REV and PLT2 are differentially expressed transcription factors that cross-repress one another in a way that reinforces specification along a given path of meristem development. Remarkably, manipulation of PLT2 or REV expression can cause reversal of meristem fates. Specifically, loss of the PLT2 repressor TOPLESS fosters expanded PLT2 gene expression in the apical region of the embryo, which leads to a shoot-to-root conversion (Figure 1A, B). In contrast, misexpression of REV under the control of the PLT2 promoter produces a root-to-shoot conversion (Figure 1C) (Aida et al. 2004; Smith and Long 2010). These and other data support a model in which REV and PLT2 antagonize the gene regulatory networks for the root and shoot meristem, respectively (see Figure 5.5 A,B; Heidstra and Sabatini 2014; Gaillochet and Lohmann 2015).
Aida, M., D. Beis, R. Heidstra, V. Willemsen and I. Blilou. 2004. The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche. Cell 119: 109–120.
Gaillochet, C. and J. U. Lohmann. 2015. The never-ending story: from pluripotency to plant developmental plasticity. Development 142:2237–2249.
Heidstra, R. and S. Sabatini. 2014. Plant and animal stem cells: similar yet different. Nat. Rev. Mol. Cell. Biol. 15: 301–312.
Smith, Z. R. and J. A. Long. 2010. Control of Arabidopsis apical-basal embryo polarity by antagonistic transcription factors. Nature 464: 423–426.
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