Further Development 8.5: Integration of Autonomous and Conditional Specification: Differentiation of the C. elegans Pharynx

Snails, Flowers, and Nematodes: Different Mechanisms for Similar Patters of Specification

It should be apparent from the discussion in Chapter 8 of the textbook that the pharynx of C. elegans is generated by two sets of cells. One group of pharyngeal precursors comes from the EMS cell and is dependent on the maternal skn-1 gene. The second group of pharyngeal precursors comes from the ABa blastomere and is dependent on GLP-1 signaling from the EMS cell. In both cases, the pharyngeal precursor cells (and only these cells) are instructed to activate the pha-4 gene (Mango et al. 1994b). The pha-4 gene encodes a transcription factor that resembles the mammalian HNF3β protein. Microarray studies by Gaudet and Mango (2002) revealed that the PHA-4 transcription factor activates almost all of the pharynx-specific genes. It appears that the PHA-4 transcription factor may be the node that takes the maternal inputs and transforms them into a signal that transcribes the zygotic genes necessary for pharynx development.

All the material on this website is protected by copyright. It may not be reproduced in any form without permission from the copyright holder.

Back to top