Neural Crest Cells and Axonal Specificity
THE NEURAL CREST
Regionalization of the Neural Crest
Neural Crest: Multipotent Stem Cells?
Specification of Neural Crest Cells
Neural Crest Cell Migration: Epithelial to Mesenchymal and Beyond
- Delamination
- The driving force of contact inhibition
- Collective migration
Migration Pathways of Trunk Neural Crest Cells
- The ventral pathway
- The dorsolateral pathway
Cranial Neural Crest
The “Chase and Run” Model
- An elaborate collaboration of pushes and pulls
Neural Crest-Derived Head Skeleton
Cardiac Neural Crest
ESTABLISHING AXONAL PATHWAYS IN THE NERVOUS SYSTEM
The Growth Cone: Driver and Engine of Axon Pathfinding
- Rho, Rho, Rho your actin filaments down the signaling stream
Axon Guidance
The Intrinsic Navigational Programming of Motor Neurons
- Cell adhesion: A mechanism to grab the road
- Local and long-range guidance molecules: The street signs of the embryo
- Repulsion patterns: Ephrins and semaphorins
How Did the Axon Cross the Road?
- …Netrin
- Slit and Robo
The Travels of Retinal Ganglion Axons
- Growth of the retinal ganglion axon to the optic nerve
- Growth of the retinal ganglion axon through the optic chiasm
Target Selection: “Are We There Yet?”
- Chemotactic proteins
- Target selection by retinal axons: “Seeing is believing”
Synapse Formation