Chapter 13 MCQs

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. The genetic polymorphism related to glucose-6-phosphate dehydrogenase was discovered as a result of

haemolysis following administration of the anti-malarial drug quinine. correct incorrect

haemolysis following administration of the anti-malarial drugs of the 8-aminoquinolines class. correct incorrect

lack of protection against malaria by administration of anti-malarial medication. correct incorrect

an inability by some individuals to taste 6-propylthiouracil. correct incorrect

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. Cytochrome CYP2D6 is NOT significant in the metabolism of which of the following classes of drugs?

Tricyclic antidepressants correct incorrect

Selective serotonin reuptake inhibitors (SSRIs) correct incorrect

Anticoagulants correct incorrect

β-Blockers correct incorrect

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. The main route of metabolism for SSRIs involving CYP2D6 is

N-demethylation. correct incorrect

hydrolysis. correct incorrect

N-oxidation. correct incorrect

dehydration. correct incorrect

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. Polymorphism of CYP2D6 can cause significant problems with respect to tamoxifen medication because

rapid metabolism decreases the blood levels of tamoxifen. correct incorrect

poor metabolism decreases the blood levels of tamoxifen. correct incorrect

poor metabolism reduces the levels of the active metabolite endoxifen. correct incorrect

rapid metabolism decreases the blood levels of the active metabolite endoxifen. correct incorrect

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. Why should rapid metabolisers of codeine avoid breastfeeding of babies?

They will not experience adequate pain relief. correct incorrect

They will experience high blood levels of morphine, a metabolite of codeine catalysed by CYP2D6. correct incorrect

They may experience morphine intoxication. correct incorrect

The metabolite morphine that is produced is excreted in breast milk and will produce morphine intoxication in the baby. correct incorrect

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. Which of the following statements about the impact of CYP2C9 polymorphism is NOT correct?

Approximately 40% of Europeans exhibit CYP2C9 polymorphism. correct incorrect

The metabolism of both isomers of warfarin involves CYP2C9. correct incorrect

Variant CYP2C9*3 reduces hydroxylation of warfarin. correct incorrect

It is advised that warfarin patients are phenotyped for CYP2C9. correct incorrect

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. Which of the following is NOT metabolised by catechol-O-methyltransferase?

Noradrenaline correct incorrect

Dopamine correct incorrect

Morphine correct incorrect

Azathioprine correct incorrect

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. Which one of these Phase II metabolic processes exhibits polymorphism?

Metabolism by sulphotransferases correct incorrect

Glucuronidation correct incorrect

Sulphation correct incorrect

Conjugation with an amino acid correct incorrect

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. Which of the following classes of drugs is NOT involved in dose adjustments resulting from pharmacogenetics studies?

Oral anticoagulants correct incorrect

β-Blockers correct incorrect

6-Mercaptopurine correct incorrect

Non-steroidal anti-inflammatory drugs (NSAIDs) correct incorrect

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. Which of the following is NOT a significant challenge for the development of pharmacogenomics?

Privacy of data correct incorrect

Little genetic testing available correct incorrect

Little data about the links between genetic disorders and complex disorders such as heart disease correct incorrect

Legal issues with respect to confidentiality of data correct incorrect