Chapter 10 Multiple Choice Questions

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. What is meant by a drug's 'specifications'?

The molecular dimensions of a molecule correct incorrect

The physical properties of a drug correct incorrect

The purity tests and purity standards required of a drug correct incorrect

The functional groups on a drug that are important to its activity correct incorrect

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. Which of the following is not a priority in chemical development?

Optimising the overall yield of a drug correct incorrect

Optimising the activity of a drug correct incorrect

Developing a cheap synthetic route correct incorrect

Optimising the purity of a drug correct incorrect

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. What term is used to describe the process by which a synthetic procedure is developed such that it is suitable for a production plant?

Plant development correct incorrect

Product development correct incorrect

Process development correct incorrect

Production development correct incorrect

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. Which of the following is not one of the twelve principles of green chemistry?

Using high temperatures to speed up reactions correct incorrect

Minimising toxic reagents used in a synthesis correct incorrect

Maximisation of atom economy correct incorrect

Minimising the use of solvents correct incorrect

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. What is meant by the optimum temperature of a reaction?

the temperature that results in the maximum possible yield. correct incorrect

the temperature that results in the minimum amount of impurities correct incorrect

the temperature that results in an acceptably high level of yield and an acceptably low level of impurities correct incorrect

none of the above correct incorrect

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. Which of the following solvents is unacceptable on large scale?

Heptane correct incorrect

Diethyl ether correct incorrect

Xylene correct incorrect

Dimethoxyethane correct incorrect

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. Which of the following procedures is not suitable for scale up

Liquid-liquid extraction correct incorrect

Crystallisation correct incorrect

Distillation correct incorrect

Rotary evaporation correct incorrect

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. Which of the following reagents is acceptable on large scale

Palladium chloride correct incorrect

Sodium dithionite correct incorrect

Pyridinium chlorochromate correct incorrect

Tin chloride correct incorrect

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. meta-Chloroperbenzoic acid (mcpba) ia preferred over simpler peroxides for carrying out the Baeyer-Villiger reaction on large scale. Which of the following statements is not a justification for this choice?

It is a cheaper reagent correct incorrect

It is a safer reagent correct incorrect

It has a higher decomposition temperature correct incorrect

It is readily available correct incorrect

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. Which of the following will not increase the yield of an equilibrium reaction?

Using a reactant in excess correct incorrect

Removal of a product by crystallisation correct incorrect

Increasing the scale of the reaction correct incorrect

Removal of a product by distillation correct incorrect